Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01279)
Name
Neostigmine
Synonyms    Click to Show/Hide the Synonyms of This API
NEOSTIGMINE; Eustigmin; Eustigmine; Prostigmine; Vagostigmine; Prostigmin; 59-99-4; Juvastigmin; m-Trimethylammoniumphenyldimethylcarbamate; Neostigmine [BAN]; 3-Trimethylammoniumphenyl N,N-dimethylcarbamate; 3-[(dimethylcarbamoyl)oxy]-N,N,N-trimethylanilinium; Vagostigmin; Neostigmine (BAN); UNII-3982TWQ96G; (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate; Prostigmin (TN); Neostigmin; CHEBI:7514; CHEMBL278020; Intrastigmina; Neostigminum; Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-N,N,N-trimethyl-; 3982TWQ96G; [3-(dimethylcarbamoyloxy)phenyl]-trimethyl-azanium bromide; 3-{[(dimethylamino)carbonyl]oxy}-N,N,N-trimethylanilinium; Benzenaminium, 3-[[(dimethylamino)carbonyl]oxy]-N,N,N-trimethyl-; 3-((dimethylcarbamoyl)oxy)-N,N,N-trimethylbenzenaminium; [3-(dimethylcarbamoyloxy)phenyl]-trimethyl-azanium; sulfonatooxymethane; CCRIS 3079; HSDB 3921; NCGC00163240-01; CAS-114-80-7; BRN 3615946; (m-Hydroxyphenyl)trimethylammonium dimethylcarbamate (ester); Ammonium, (m-hydroxyphenyl)trimethyl-, dimethylcarbamate (ester); [3-(dimethylcarbamoyloxy)phenyl]-trimethylazanium; Spectrum_001061; Prestwick0_000468; Prestwick1_000468; Prestwick2_000468; Prestwick3_000468; Spectrum2_001278; Spectrum4_000072; Spectrum5_001234; Lopac-N-2001; bmse000762; Lopac0_000816; SCHEMBL34419; BSPBio_000576; KBioGR_000623; KBioSS_001541; [3-(dimethylcarbamoyloxy)phenyl]-trimethyl-azanium; DivK1c_000165; DivK1c_000198; SPBio_001276; SPBio_002515; BPBio1_000634; GTPL8993; ZINC1792; DTXSID1023360; ALWKGYPQUAPLQC-UHFFFAOYSA-; KBio1_000165; KBio1_000198; KBio2_001541; KBio2_004109; KBio2_006677; NINDS_000165; NINDS_000198; HMS2089A22; BDBM50022775; STL058953; AKOS005711366; CCG-204900; DB01400; MCULE-3501840981; IDI1_000165; IDI1_000198; MLS-0002855; NCGC00015730-01; NCGC00015730-02; NCGC00015730-03; NCGC00015730-04; NCGC00015730-05; NCGC00015730-06; NCGC00015730-07; NCGC00015730-08; NCGC00015730-09; NCGC00015730-24; NCGC00021658-03; SBI-0050793.P004; AB00053807; C07258; D08261; AB00053807-25; AB00053807-26; AB00053807_27; AB00053807_28; AB00053807_29; Q410546; BRD-K18922609-004-04-1; BRD-K18922609-004-14-0; Benzenaminium, 3-(((dimethylamino)carbonyl)oxy)-N,N,N-trimethyl- (9CI)
Clinical Status
Approved
PubChem CID
4456
Formula
C12H19N2O2+
Canonical SMILES
CN(C)C(=O)OC1=CC=CC(=C1)[N+](C)(C)C
InChI
1S/C12H19N2O2/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5/h6-9H,1-5H3/q+1
InChIKey
ALWKGYPQUAPLQC-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4456"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 223.29 Topological Polar Surface Area 29.5
XlogP 1.5 Complexity 246
Heavy Atom Count 16 Rotatable Bond Count 3
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Neostigmine 3mg/3ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Phenol; Sodium Acetate Trihydrate; Water For Injection
                   Dosage Form Solution
                   Company Fresenius Kabi Usa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Phenol DIG Info Carbonic anhydrase III (Ki = 2700 nM) [1]
Sodium acetate DIG Info Carbonic anhydrase I (Ki = 10800 nM) [2]
          Neostigmine 5mg/10ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Phenol; Sodium Acetate Trihydrate; Water For Injection
                   Dosage Form Solution
                   Company Exela Pharma; Fresenius Kabi Usa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Phenol DIG Info Carbonic anhydrase III (Ki = 2700 nM) [1]
Sodium acetate DIG Info Carbonic anhydrase I (Ki = 10800 nM) [2]
          Neostigmine 10mg/10ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Phenol; Sodium Acetate Trihydrate; Water For Injection
                   Dosage Form Solution
                   Company Exela Pharma; Fresenius Kabi Usa
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Phenol DIG Info Carbonic anhydrase III (Ki = 2700 nM) [1]
Sodium acetate DIG Info Carbonic anhydrase I (Ki = 10800 nM) [2]
References
1 Synthesis of C-cinnamoyl glycosides and their inhibitory activity against mammalian carbonic anhydrases. Bioorg Med Chem. 2013 Mar 15; 21(6):1489-94.
2 Carbonic anhydrase inhibitors. Inhibition of the -class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2521-6.

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