Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00262) | |||||
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Name |
Ezetimibe
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Synonyms |
Click to Show/Hide the Synonyms of This API
Ezetimibe; 163222-33-1; Ezetrol; Ezedoc; Sch 58235; SCH-58235; SCH58235; UNII-EOR26LQQ24; Ezetimibe (Zetia); EOR26LQQ24; CHEBI:49040; DSSTox_CID_24223; DSSTox_RID_80127; DSSTox_GSID_44223; (-)-Sch 58235; SMR000466334; CAS-163222-33-1; Zetia (TN); C24H21F2NO3; ezetimiba; ezetimibum; Ezetimibe [USAN:INN:BAN]; MFCD00937872; HSDB 7737; ezetimibe anhydrate; NCGC00095134-01; MK-0653; SCHEMBL2871; CHEMBL1138; Ezetimibe (JAN/USP/INN); cc-336; MLS000759443; MLS001424125; MLS006011921; GTPL6816; DTXSID1044223; Ezetimibe, >=98% (HPLC); EX-A795; HMS2051K16; HMS2236A04; HMS3715D06; ACT03511; ZINC3810860; Tox21_111443; ABP001091; BDBM50371521; MK0653; STK640490; AKOS005572111; Tox21_111443_1; AC-1057; AM84560; CCG-100884; CS-1016; DB00973; KS-1170; MCULE-4417284526; NC00134; NCGC00263575-01; NCGC00263575-07; HY-17376; AB0011316; D01966; K-5098; 28055-EP2272841A1; 28055-EP2280001A1; 28055-EP2287165A2; 28055-EP2287166A2; 28055-EP2292620A2; 28055-EP2294052A1; 28055-EP2295422A2; 28055-EP2298742A1; 28055-EP2298769A1; 28055-EP2298776A1; 28055-EP2301923A1; 28055-EP2301936A1; 28055-EP2308878A2; 28055-EP2314588A1; AB00639916-06; AB00639916-08; AB00639916_09; 222E331; AR-270/43507897; Q417997; 3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one; BRD-K42260897-001-09-2; Z1550648770; (3R,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-; Ezetimibe, United States Pharmacopeia (USP) Reference Standard; Ezetimibe, Pharmaceutical Secondary Standard; Certified Reference Material
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Clinical Status |
Approved
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Disease Indication | Hypertriglyceridaemia | ICD-11: 5C80 | [1] | ||
PubChem CID | |||||
Formula |
C24H21F2NO3
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Canonical SMILES |
C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O
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InChI |
1S/C24H21F2NO3/c25-17-5-1-15(2-6-17)22(29)14-13-21-23(16-3-11-20(28)12-4-16)27(24(21)30)19-9-7-18(26)8-10-19/h1-12,21-23,28-29H,13-14H2/t21-,22+,23-/m1/s1
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InChIKey |
OLNTVTPDXPETLC-XPWALMASSA-N
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Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
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3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 409.4 | Topological Polar Surface Area | 60.8 | |
XlogP | 4 | Complexity | 567 | ||
Heavy Atom Count | 30 | Rotatable Bond Count | 6 | ||
Hydrogen Bond Donor Count | 2 | Hydrogen Bond Acceptor Count | 5 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
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Ezetimibe 10 mg tablet | Click to Show/Hide the Full List of Formulation(s): 13 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Sodium stearyl fumarate; Magnesium stearate; Crospovidone; Povidone; Cellulose, microcrystalline; Starch, pregelatinized corn
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Dosage Form | Oral Tablet | |||||
Company | Cadila Healthcare; Zydus Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Sodium stearyl fumarate | DIG Info | Leukemia K562 cells (IC50 = 20.2 ug.mL-1) | [3] | |||
Povidone | DIG Info | Cholesterol 25-hydroxylase (IC50 = 78.3 uM) | [4] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Crospovidone | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Povidone; Silicon dioxide; Cellulose, microcrystalline
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Dosage Form | Oral Tablet | |||||
Company | Apotex; AvKARE | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Povidone | DIG Info | Cholesterol 25-hydroxylase (IC50 = 78.3 uM) | [4] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [5] | |||
Silicon dioxide | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Povidone; Cellulose, microcrystalline
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Dosage Form | Oral Tablet | |||||
Company | A-S Medication Solutions; Physicians Total Care | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Povidone | DIG Info | Cholesterol 25-hydroxylase (IC50 = 78.3 uM) | [4] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [5] | |||
Drug Formulation 4 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Crospovidone (15 mpa.s at 5%); Hypromellose 2208 (3 mpa.s); Microcrystalline cellulose
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Dosage Form | Oral Tablet | |||||
Company | Aurobindo Pharma | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [5] | |||
Drug Formulation 5 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Crospovidone, unspecified; Hypromellose 2910 (3 mpa.s); Microcrystalline cellulose
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Dosage Form | Oral Tablet | |||||
Company | Actavis Pharma | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [5] | |||
Drug Formulation 6 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline; Hypromellose 2910 (15 mpa.s)
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Dosage Form | Oral Tablet | |||||
Company | Bryant Ranch Prepack; Sandoz | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [5] | |||
Drug Formulation 7 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Povidone, unspecified; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Golden State Medical Supply | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [5] | |||
Drug Formulation 8 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Povidones; Starch, corn
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Dosage Form | Oral Tablet | |||||
Company | Ohm Laboratories | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [5] | |||
Drug Formulation 9 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline; Povidones
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Dosage Form | Oral Tablet | |||||
Company | RemedyRepack | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [5] | |||
Drug Formulation 10 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Microcrystalline cellulose; Povidone, unspecified
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Dosage Form | Oral Tablet | |||||
Company | A-S Medication Solutions; Prasco | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [5] | |||
Drug Formulation 11 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Croscarmellose sodium; Cellulose, microcrystalline; Povidones
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Dosage Form | Oral Tablet | |||||
Company | Cardinal Health | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [5] | |||
Drug Formulation 12 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Sodium lauryl sulfate; Magnesium stearate; Povidones
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Dosage Form | Oral Tablet | |||||
Company | American Health Packaging; Glenmark Pharmaceutials; Par Pharmaceutical | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Sodium lauryl sulfate | DIG Info | Solute carrier SLCO2B1 (Ki = 1.98 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Drug Formulation 13 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM Lactose monohydrate; Magnesium stearate; Croscarmellose sodium; Povidone; Sodium laureth-12 sulfate
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Dosage Form | Oral Tablet | |||||
Company | Amneal Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Povidone | DIG Info | Cholesterol 25-hydroxylase (IC50 = 78.3 uM) | [4] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [5] | |||
Carmellose sodium | DIG Info | Albendazole monooxygenase (Protein expression upregulation) | [5] | |||
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