Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00653)
Name
Tedizolid phosphate
Synonyms    Click to Show/Hide the Synonyms of This API
Tedizolid phosphate; Torezolid phosphate; 856867-55-5; Tedizolid (phosphate); TR-701FA; UNII-O7DRJ6R4DW; CHEBI:83326; TR-701 FA; O7DRJ6R4DW; (R)-(3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl dihydrogen phosphate; TR-701; TR-701-FA; 856867-55-5 (phosphate); NE63553; (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one dihydrogenphosphate; [(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl dihydrogen phosphate; [(5R)-3-{3-fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl]methyl dihydrogen phosphate; Tedizolid phosphate [USAN]; Sivextro (TN); C17H16FN6O6P; SCHEMBL1557561; CHEMBL2105669; Tedizolid phosphate (JAN/USAN); DTXSID30234977; BCP10960; 9050AF; BDBM50017198; HY-14855B; MFCD28098176; ZINC43100953; AKOS027250820; CCG-269233; CS-5004; DB09042; NCGC00482851-02; AS-57141; D09686; TR701-FA; TR-701-FA; TR 701-FA; Q21011227; ((5R)-3-(3-Fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5- yl)methyl hydrogen phosphate; 2-Oxazolidinone, 3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl)phenyl)-5- ((phosphonooxy)methyl)-, (5R)-
Clinical Status
Approved
Disease Indication Streptococcus bacterial infection ICD-11: 1C41 [1]
PubChem CID
11476460
Formula
C17H16FN6O6P
Canonical SMILES
CN1N=C(N=N1)C2=NC=C(C=C2)C3=C(C=C(C=C3)N4C[C@@H](OC4=O)COP(=O)(O)O)F
InChI
1S/C17H16FN6O6P/c1-23-21-16(20-22-23)15-5-2-10(7-19-15)13-4-3-11(6-14(13)18)24-8-12(30-17(24)25)9-29-31(26,27)28/h2-7,12H,8-9H2,1H3,(H2,26,27,28)/t12-/m1/s1
InChIKey
QCGUSIANLFXSGE-GFCCVEGCSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=11476460"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 450.3 Topological Polar Surface Area 153
XlogP 0.3 Complexity 702
Heavy Atom Count 31 Rotatable Bond Count 6
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 11
Full List of Drug Formulations (DFMs) Containing This API
          Tedizolid phosphate 200 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Mannitol; Ferric oxide yellow; Talc; Titanium dioxide; Crospovidone (15 mpa.s at 5%); Microcrystalline cellulose; Polyethylene glycol, unspecified; Polyvinyl alcohol, unspecified; Povidone, unspecified
                   Dosage Form Oral Tablet
                   Company Merck Sharp & Dohme
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Mannitol DIG Info Glycine receptor alpha-1 (EC50 = 12589.25 nM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved tedizolid phosphate from the official website of the U.S. Food and Drug Administration.
2 Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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