Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00817)
Name
Alcaftadine
Synonyms    Click to Show/Hide the Synonyms of This API
Alcaftadine; 147084-10-4; Lastacaft; R89674; UNII-7Z8O94ECSX; R-89674; R 89674; 7Z8O94ECSX; CHEBI:71023; 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine-3-carbaldehyde; Lastacaft (TN); 2-(1-Methylpiperidin-4-ylidene)-4,7-diazatricyclo[8.4.0.0(3,7)]tetradeca- 1(14),3,5,10,12-pentaene-6-carbaldehyde; Alcaftadine [USAN:INN]; alcaftadina; alcaftadinum; 1794775-80-6; Alcaftadine (JAN/USAN/INN); GTPL7587; SCHEMBL1602418; CHEMBL1201747; Alcaftadine, >=98% (HPLC); (Unlabelled)Alcaftadine-13C-D3; AOB6728; DTXSID80598455; HMS3885B12; BCP04261; MFCD09954106; s4625; ZINC11726211; AKOS025402002; AM84429; BCP9000269; CCG-267551; DB06766; NCGC00390732-04; AC-28019; AS-56303; HY-17039; BCP0726000082; DB-063693; FT-0661472; X6443; A16393; D06552; Q4712900; 11-(1-methylpiperidin-4-ylidene)-5,6-dihydroimidazo[2,1-b][3]benzazepine-3-carbaldehyde; 11-(1-methylpiperidin-4-ylidene)-5,6-dihydroimidazo[2,3-b][3]benzazepine-3-carbaldehyde; 2-(1-methylpiperidin-4-ylidene)-4,7-diazatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),3,5,10,12-pentaene-6-carbaldehyde; 5H-Imidazo(2,1-b)(3)benzazepine-3-carboxaldehyde, 6,11-dihydro-11-(1-methyl-4- piperidinylidene)-; 5H-Imidazo[2,1-b][3]benzazepine-3-carboxaldehyde, 6,11-dihydro-11-(1-methyl-4-piperidinylidene)-
Clinical Status
Approved
PubChem CID
19371515
Formula
C19H21N3O
Canonical SMILES
CN1CCC(=C2C3=CC=CC=C3CCN4C2=NC=C4C=O)CC1
InChI
1S/C19H21N3O/c1-21-9-6-15(7-10-21)18-17-5-3-2-4-14(17)8-11-22-16(13-23)12-20-19(18)22/h2-5,12-13H,6-11H2,1H3
InChIKey
MWTBKTRZPHJQLH-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=19371515"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 307.4 Topological Polar Surface Area 38.1
XlogP 1.7 Complexity 479
Heavy Atom Count 23 Rotatable Bond Count 1
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Alcaftadine 0.25% solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Benzalkonium Chloride; Edetate Disodium; Sodium Phosphate, Monobasic; Purified Water; Sodium Chloride
                   Dosage Form Solution
                   Company Allergan
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Benzalkonium chloride DIG Info Solute carrier SLCO2B1 (Ki = 62.1 uM) [1]
References
1 Bacterial metabolism rescues the inhibition of intestinal drug absorption by food and drug additives. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):16009-16018.

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