Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01238)
Name
Mepivacaine
Synonyms    Click to Show/Hide the Synonyms of This API
mepivacaine; 96-88-8; N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide; Carbocaine; DL-Mepivacaine; Scandicain; Scandicaine; Mepivacaina; Mepivacainum; Mepicaine; Mepivicaine; Polocaine; 22801-44-1; Mepivacainum [INN-Latin]; Mepivacaina [INN-Spanish]; (+-)-1-Methyl-2',6'-pipecoloxylidide; Carbocain; N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide; Polocaine-Mpf; 2-Piperidinecarboxamide, N-(2,6-dimethylphenyl)-1-methyl-; 1-METHYL-2',6'-PIPECOLOXYLIDIDE; N-Methyl-2-pipecolic acid, 2,6-xylidide; 2',6'-Pipecoloxylidide, 1-methyl-; N-Methyl-2-pipecolic acid, 2,6-dimethylanilide; CHEBI:6759; N-Methylhexahydro-2-picolinic acid, 2,6-dimethylanilide; Mepihexal; Scandicane; BRN 0211230; Mepivacaine [INN:BAN]; S-Ropivacaine Mesylate; Mepivacaine (INN); Carboplyin Dental (TN); 5-22-01-00223 (Beilstein Handbook Reference); EINECS 202-543-0; Mepivacain; Spectrum_001480; SpecPlus_000874; Spectrum2_001656; Spectrum3_001629; Spectrum4_000596; Spectrum5_001354; (.+/-.)-Mepivacaine; Epitope ID:122686; CHEMBL1087; SCHEMBL25314; BSPBio_003297; KBioGR_001092; KBioSS_001960; MLS006011662; DivK1c_006970; SPBio_001811; GTPL7224; DTXSID9023259; KBio1_001914; KBio2_001960; KBio2_004528; KBio2_007096; KBio3_002517; APF-135; HMS3886E04; BDBM50417964; MFCD00243006; s5392; AKOS015889304; AC-9857; CCG-266926; DB00961; FS-3679; MCULE-7228754802; NCGC00018284-02; NCGC00018284-03; NCGC00018284-05; NCGC00018284-06; NCGC00089774-02; AK105914; SMR004703413; SBI-0052814.P002; FT-0653428; Z5419; (.+/-.)-1-Methyl-2',6'-pipecoloxylidide; 22M629; C07528; D08181; M-8373; AB00053769_12; AB00053769_13; A816361; Q416760; Q-100290; BRD-A03216249-003-02-9; BRD-A03216249-003-12-8; N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide #; N-(2,6-dimethylphenyl)-1-methyl-piperidine-2-carboxamide; N-(2,6-dimethylphenyl)-1-methylpiperidine-2-carboximidic acid
Clinical Status
Approved
PubChem CID
4062
Formula
C15H22N2O
Canonical SMILES
CC1=C(C(=CC=C1)C)NC(=O)C2CCCCN2C
InChI
1S/C15H22N2O/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18)
InChIKey
INWLQCZOYSRPNW-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=4062"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 246.35 Topological Polar Surface Area 32.299
XlogP 1.9 Complexity 282
Heavy Atom Count 18 Rotatable Bond Count 2
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Mepivacaine 10mg/1ml solution Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium Chloride; Potassium Chloride; Calcium Chloride; Water; Sodium Hydroxide; Hydrochloric Acid
                   Dosage Form Solution
                   Company Hospira
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Potassium chloride DIG Info Carbonic anhydrase IV (Ki = 90000 nM) [1]
Hydrochloric acid DIG Info Carbonic anhydrase V (Ki = 156 nM) [2]
          Mepivacaine 30mg/ml solution Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium Chloride; Sodium Hydroxide; Water
                   Dosage Form Solution
                   Company Patterson Dental Supply
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Sodium Chloride; Water
                   Dosage Form Solution
                   Company Pearson Dental
References
1 Characterization and anions inhibition studies of an -carbonic anhydrase from the teleost fish Dicentrarchus labrax. Bioorg Med Chem. 2011 Jan 15; 19(2):744-8.
2 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.

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