Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01489)
Name	Tirbanibulin
Synonyms	Click to Show/Hide the Synonyms of This API KX2-391; 897016-82-9; Tirbanibulin; KX-01; UNII-4V9848RS5G; KX-2-391; N-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide; KX-2391; CHEMBL571546; 4V9848RS5G; KX2391; KX2-391;KX-01; 2-Pyridineacetamide,5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-; 2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]-~{N}-(phenylmethyl)ethanamide; KX 01; Klisyri; Tirbanibulin [USAN]; Tirbanibulin (USAN/INN); cc-266; MLS006011272; SCHEMBL153779; GTPL7957; KX01; DTXSID30237862; HMS3656J15; HMS3673E15; BCP02845; EX-A2434; BDBM50303801; NSC756643; NSC800779; s2700; WHO 10864; ZINC43152787; N-benzyl-2-(5-{4-[2-(morpholin-4-yl)ethoxy]phenyl}pyridin-2-yl)acetamide; N-benzyl-2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]acetamide; BCP9000828; CCG-264983; CS-0248; DB06137; KX2-391; KX-01; NSC-756643; NSC-800779; SB16619; 2-Pyridineacetamide, 5-(4-(2-(4-morpholinyl)ethoxy)phenyl)-n-(phenylmethyl)-; NCGC00346644-01; NCGC00346644-05; AK241704; AS-73245; HY-10340; KX 2-391; SMR004703022; DB-119272; SW219670-1; X7515; D11691; W-5764; BRD-K29968218-001-01-6; Q27888424; 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide; 2-(5-(4-(2-morpholinoethoxyl)phenyl)pyridin-2-yl)-N-benzylacetamide; 2-[5-[4-(2-morpholin-4-ylethoxy)phenyl]pyridin-2-yl]-N-(phenylmethyl)acetamide; 5-[4-[2-(4-Morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-2-pyridineacetamide; DN0
Clinical Status	Approved
PubChem CID	23635314
Formula	C26H29N3O3
Canonical SMILES	C1COCCN1CCOC2=CC=C(C=C2)C3=CN=C(C=C3)CC(=O)NCC4=CC=CC=C4
InChI	1S/C26H29N3O3/c30-26(28-19-21-4-2-1-3-5-21)18-24-9-6-23(20-27-24)22-7-10-25(11-8-22)32-17-14-29-12-15-31-16-13-29/h1-11,20H,12-19H2,(H,28,30)
InChIKey	HUNGUWOZPQBXGX-UHFFFAOYSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=23635314"></iframe>
Structure	3D MOL is unavailable		2D MOL
Physicochemical Properties	Molecular Weight	431.5	Topological Polar Surface Area	63.7
	XlogP	2.9	Complexity	540
	Heavy Atom Count	32	Rotatable Bond Count	9
	Hydrogen Bond Donor Count	1	Hydrogen Bond Acceptor Count	5

Full List of Drug Formulations (DFMs) Containing This API
Tirbanibulin 1% ointment			Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Mono-Glycerides; Di-Glycerides; Propylene Glycol
Dosage Form	Ointment
Company	Almirall
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Propylene glycol	DIG Info	Albendazole monooxygenase (Inhibition ratio < 20 %)	[1]

References
1	Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration. Eur J Pharm Biopharm. 2008 Sep;70(1):279-88.

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