Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET01QAN) | |||||
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| Name |
CDK2-CCNA2 complex (CDK2-CCNA2)
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| Synonyms |
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Cell division protein kinase 2 complexed with Cyclin-A2; Cyclin-dependent kinase 2 complexed with Cyclin-A2; p33 protein kinase complexed with Cyclin-A2
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| Family | Transferase (TFase) >> Kinase (EC 2.7) | ||||
| Organism |
Homo sapiens (Human)
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| UniProt ID | CDK2_HUMAN | (click to find more protein-related data of this DBT) | |||
| CCNA2_HUMAN | (click to find more protein-related data of this DBT) | ||||
| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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| DIG Name: Raffinose | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Lyophilization aid
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 16 nM (estimated based on the structural similarity with CHEMBL1744450 ) | [1] | ||||
| Structural Similarity | Tanimoto coefficient = 1 | |||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CDK2_HUMAN ; CCNA2_HUMAN | |||||
| References | |||||
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| 1 | Optimization of 6,6-dimethyl pyrrolo[3,4-c]pyrazoles: Identification of PHA-793887, a potent CDK inhibitor suitable for intravenous dosing. Bioorg Med Chem. 2010 Mar 1; 18(5):1844-53. | ||||
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