Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET02FLN) | |||||
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| Name |
Vanilloid receptor 1 (TrpV1)
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| Synonyms |
Click to Show/Hide the Synonyms of This DBT
Transient receptor potential cation channel V1; Capsaicin receptor; OTRPC1; Osm-9-like TRP channel 1; Transient receptor potential cation channel subfamily V member 1; TrpV1; VR1
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| Family | Transmembrane channel/porin (TC/P) >> Transient receptor potential Ca channel (TRP-CC) | ||||
| Organism |
Homo sapiens (Human)
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| Gene Name | TRPV1 | Gene ID | |||
| UniProt ID | TRPV1_HUMAN | (click to find more protein-related data of this DBT) | |||
| TTD ID | T83193 | (click to find more therapeutic target data of this DBT) | |||
| Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target | |||||
| Sequence |
MKKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLFGKGDSEEAFP
VDCPHEEGELDSCPTITVSPVITIQRPGDGPTGARLLSQDSVAASTEKTLRLYDRRSIFE AVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNTTIPLLLEI ARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHGDFFKKT KGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHALVEVADNTA DNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQE PECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLN RLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKTGDYFRVTGEIL SVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLYFSHLKEYVAS MVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLFGFSTAVVTLIE DGKNDSLPSESTSHRWRGPACRPPDSSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVF IILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKA FRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRS SRVSGRHWKNFALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK |
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| Function |
Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.
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| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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| DIG Name: Lauric diethanolamide | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
 click to show the detail info of this DIG
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Surfactant; Viscosity-controlling agent
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | EC50 = 600 nM (estimated based on the structural similarity with CHEMBL206425 ) | [1] | ||||
| Structural Similarity | Tanimoto coefficient = 0.927272727 | |||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | TRPV1_HUMAN | |||||
| References | |||||
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| 1 | Oxyhomologues of anandamide and related endolipids: chemoselective synthesis and biological activity. J Med Chem. 2006 Apr 6; 49(7):2333-8. | ||||
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