Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET02KFG) | |||||
|---|---|---|---|---|---|
| Name |
Muscarinic receptor (CHRM)
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| Family | G-protein coupled receptor (GPCR) >> G-protein coupled rhodopsin receptor (GPCR-A) | ||||
| Organism |
Homo sapiens (Human)
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| UniProt ID | ACM1_HUMAN | (click to find more protein-related data of this DBT) | |||
| ACM2_HUMAN | (click to find more protein-related data of this DBT) | ||||
| ACM3_HUMAN | (click to find more protein-related data of this DBT) | ||||
| ACM4_HUMAN | (click to find more protein-related data of this DBT) | ||||
| ACM5_HUMAN | (click to find more protein-related data of this DBT) | ||||
| TTD ID | T09130 | (click to find more therapeutic target data of this DBT) | |||
| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
|---|---|---|---|---|---|---|
| DIG Name: Methylpyrrolidone | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Penetration agent; Solubilizing agent; Solvent
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 13 nM (estimated based on the structural similarity with CHEMBL23957 ) | [1] | ||||
| Structural Similarity | Tanimoto coefficient = 0.87804878 | |||||
| Tested Species | Rattus norvegicus (Rat) | |||||
| UniProt ID | ACM1_RAT ; ACM2_RAT ; ACM3_RAT ; ACM4_RAT ; ACM5_RAT | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Substituent variation in azabicyclic triazole- and tetrazole-based muscarinic receptor ligands. J Med Chem. 1992 Jun 26; 35(13):2392-406. | ||||
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