Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET04ZFL)
Name
Indoleamine 2,3-dioxygenase 1 (IDO1)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Indoleamine-pyrrole 2,3-dioxygenase; IDO; IDO-1; INDO
Family Oxidoreductase (ORase)  >>  Oxygen single donor oxidoreductase (EC 1.13)
Organism
Homo sapiens (Human)
Gene Name IDO1 Gene ID
3620
UniProt ID I23O1_HUMAN (click to find more protein-related data of this DBT)
TTD ID T89697 (click to find more therapeutic target data of this DBT)
INTEDE ID DME0171 (click to find more drug-metabolizing enzyme data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
Function
Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan.
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Benzyl alcohol Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative; Solvent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 1400 nM (estimated based on the structural similarity with CHEMBL3763371 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.848101266
                   Tested Species Homo sapiens (Human)
                   UniProt ID I23O1_HUMAN
          DIG Name: Tryptophan Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Buffering agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 498700 nM (tested by experiment) [2]
                   Tested Species Homo sapiens (Human)
                   UniProt ID I23O1_HUMAN
References
1 O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1. Eur J Med Chem. 2016 Jan 27; 108:564-576.
2 Recent synthetic and medicinal perspectives of tryptanthrin. Bioorg Med Chem. 2017 Sep 1; 25(17):4533-4552.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.