Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET05LSS)
Name
Serine racemase (SRR)
Synonyms    Click to Show/Hide the Synonyms of This DBT
D-serine ammonia-lyase; D-serine dehydratase; L-serine ammonia-lyase; L-serine dehydratase
Family Lyase/isomerase/ligase (L/I/G)  >>  Racemase/epimerase (EC 5.1)
Organism
Homo sapiens (Human)
Gene Name SRR Gene ID
63826
UniProt ID SRR_HUMAN (click to find more protein-related data of this DBT)
TTD ID T00477 (click to find more therapeutic target data of this DBT)
INTEDE ID DME0588 (click to find more drug-metabolizing enzyme data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MCAQYCISFADVEKAHINIRDSIHLTPVLTSSILNQLTGRNLFFKCELFQKTGSFKIRGA
LNAVRSLVPDALERKPKAVVTHSSGNHGQALTYAAKLEGIPAYIVVPQTAPDCKKLAIQA
YGASIVYCEPSDESRENVAKRVTEETEGIMVHPNQEPAVIAGQGTIALEVLNQVPLVDAL
VVPVGGGGMLAGIAITVKALKPSVKVYAAEPSNADDCYQSKLKGKLMPNLYPPETIADGV
KSSIGLNTWPIIRDLVDDIFTVTEDEIKCATQLVWERMKLLIEPTAGVGVAAVLSQHFQT
VSPEVKNICIVLSGGNVDLTSSITWVKQAERPASYQSVSV
Function
D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. Catalyzes the synthesis of D-serine from L-serine.
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Aminoethanoic acid Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Buffering agent; Disintegrant; Lyophilization aid
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity Ki = 366000 nM (tested by experiment) [1]
                   Tested Species Homo sapiens (Human)
                   UniProt ID SRR_HUMAN
References
1 In silico and pharmacological screenings identify novel serine racemase inhibitors. Bioorg Med Chem Lett. 2014 Aug 15; 24(16):3732-5.

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