Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET07JKB)
Name
Leukemia MT4 cells (MT4)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Human acute lymphoblastic leukemia MT4 cells; MT-4
Family Cell line (CELL)  >>  Blood cell line (BLOcel)
Organism
Homo sapiens (Human)
Cellosaurus ID CVCL_2632 (click to find more cell line data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Food blue 1 aluminum lake Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Colorant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 1288.25 nM (estimated based on the structural similarity with CHEMBL202316 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.78807947
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_2632
          DIG Name: Hyaluronate sodium Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Humectant; Lubricant; Modified-release agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity EC50 = 5.4 ug.mL-1 (estimated based on the structural similarity with CHEMBL214326 ) [2]
                   Structural Similarity Tanimoto coefficient = 0.92173913
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_2632
References
1 Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogues. J Med Chem. 2006 Feb 23; 49(4):1291-312.
2 Preparation and anti-HIV activity of O-acylated heparin and dermatan sulfate derivatives with low anticoagulant effect. J Med Chem. 1993 Nov 12; 36(23):3546-55.

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