Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET07PQC)
Name	DNA polymerase beta (POLB)
Synonyms	Click to Show/Hide the Synonyms of This DBT DNA polymerase (pol) beta; Polb
Family	Transferase (TFase) >> Kinase (EC 2.7)
Organism	Homo sapiens (Human)
Gene Name	POLB		Gene ID	5423
UniProt ID	DPOLB_HUMAN	(click to find more protein-related data of this DBT)
	Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence	MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
Function	Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
DIG Name: Cholesterol		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Emollient; Emulsifying agent
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	IC50 > 500000 nM (tested by experiment)		[1]
Tested Species	Rattus norvegicus (Rat)
UniProt ID	DPOLB_RAT

References
1	Molecular design of cholesterols as inhibitors of DNA polymerase alpha. J Med Chem. 2004 Sep 23; 47(20):4971-4.

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