Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET08VBN)
Name
UDP/CysLT receptor (GPR17)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Uracil nucleotide/cysteinyl leukotriene receptor; G-protein coupled receptor 17; R12; P2Y-like receptor
Family G-protein coupled receptor (GPCR)  >>  G-protein coupled rhodopsin receptor (GPCR-A)
Organism
Homo sapiens (Human)
Gene Name GPR17 Gene ID
2840
UniProt ID GPR17_HUMAN (click to find more protein-related data of this DBT)
TTD ID T33902 (click to find more therapeutic target data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MSKRSWWAGSRKPPREMLKLSGSDSSQSMNGLEVAPPGLITNFSLATAEQCGQETPLENM
LFASFYLLDFILALVGNTLALWLFIRDHKSGTPANVFLMHLAVADLSCVLVLPTRLVYHF
SGNHWPFGEIACRLTGFLFYLNMYASIYFLTCISADRFLAIVHPVKSLKLRRPLYAHLAC
AFLWVVVAVAMAPLLVSPQTVQTNHTVVCLQLYREKASHHALVSLAVAFTFPFITTVTCY
LLIIRSLRQGLRVEKRLKTKAVRMIAIVLAIFLVCFVPYHVNRSVYVLHYRSHGASCATQ
RILALANRITSCLTSLNGALDPIMYFFVAEKFRHALCNLLCGKRLKGPPPSFEGKTNESS
LSAKSEL
Function
Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia.
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Tryptophan Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Buffering agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 > 30000 nM (tested by experiment) [1]
                   Tested Species Homo sapiens (Human)
                   UniProt ID GPR17_HUMAN
References
1 3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17. J Med Chem. 2018 Sep 27; 61(18):8136-8154.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.