Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET08ZOL)
Name	Lung cancer NCI-H460 cells (NCI-H460)
Synonyms	Click to Show/Hide the Synonyms of This DBT Human lung carcinoma NCI-H460 cells; NCI.H460; H460; H-460; NCIH460; NCI-HUT-460; NCI-460
Family	Cell line (CELL) >> Lung cell line (LUNcel)
Organism	Homo sapiens (Human)
Cellosaurus ID	CVCL_0459	(click to find more cell line data of this DBT)

Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
DIG Name: Acetylated sucrose distearate		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Emollient
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	IC50 = 32000 nM (estimated based on the structural similarity with CHEMBL3589571 )		[1]
Structural Similarity	Tanimoto coefficient = 0.926470588
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0459
DIG Name: Diethylene glycol monoethyl ether		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Solubilizing agent; Solvent
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	IC50 > 100000 nM (estimated based on the structural similarity with CHEMBL155204 )		[2]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0459

References
1	Structure activity relationship study of Mezzettiasides natural products and their four new disaccharide analogues for anticancer/antibacterial activity. Medchemcomm. 2014 Aug; 5(8):1138-1142.
2	Antitumor potential of crown ethers: structure-activity relationships, cell cycle disturbances, and cell death studies of a series of ionophores. J Med Chem. 2007 Mar 8; 50(5):1007-18.

If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.