Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET0E1VF) | |||||
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| Name |
Catalase (CAT)
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| Synonyms |
Click to Show/Hide the Synonyms of This DBT
Manganese containing Mn(III) in resting state; Cat; CAT
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| Family | Oxidoreductase (ORase) >> Peroxidase (EC 1.11) | ||||
| Organism |
Homo sapiens (Human)
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| Gene Name | CAT | Gene ID | |||
| UniProt ID | CATA_HUMAN | (click to find more protein-related data of this DBT) | |||
| TTD ID | T01597 | (click to find more therapeutic target data of this DBT) | |||
| INTEDE ID | DME0090 | (click to find more drug-metabolizing enzyme data of this DBT) | |||
| Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target | |||||
| Sequence |
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL |
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| Function |
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.
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| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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| DIG Name: Calcium ascorbate anhydrous | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Antioxidant
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | EC50 = 1.37 ug.mL-1 (estimated based on the structural similarity with CHEMBL196 ) | [1] | ||||
| Structural Similarity | Tanimoto coefficient = 1 | |||||
| Tested Species | Rattus norvegicus (Rat) | |||||
| UniProt ID | CATA_RAT | |||||
| References | |||||
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| 1 | Synthesis, spectral characterization and biological evaluation of phosphorylated derivatives of galanthamine. Eur J Med Chem. 2010 Jan; 45(1):203-9. | ||||
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