Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0E4DQ)
Name
Fetal lung MRC5 cells (MRC5)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Human fetal lung MRC5 cells; MRC-5; MRC 5; MRCV; MRC-V; Medical Research Council cell strain-5
Family Cell line (CELL)  >>  Lung cell line (LUNcel)
Organism
Homo sapiens (Human)
Cellosaurus ID CVCL_0440 (click to find more cell line data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Lactic acid Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Acidulant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 23930 nM (estimated based on the structural similarity with CHEMBL330546 ) [1]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0440
References
1 Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification. Eur J Med Chem. 2017 Sep 29; 138:644-660.

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