Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0EN9M)
Name
Casein kinase II alpha (CSNK2A1)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Casein kinase II subunit alpha; Protein kinase CK2; CK II; CK II alpha; CK2A1
Family Transferase (TFase)  >>  Kinase (EC 2.7)
Organism
Homo sapiens (Human)
Gene Name CSNK2A1 Gene ID
1457
UniProt ID CSK21_HUMAN (click to find more protein-related data of this DBT)
TTD ID T51565 (click to find more therapeutic target data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINIT
NNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTD
FKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAE
FYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYD
QLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDF
LDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPT
PSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
Function
Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage.
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Naphthol yellow S Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Colorant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 400 nM (estimated based on the structural similarity with CHEMBL459510 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.788888889
                   Tested Species Homo sapiens (Human)
                   UniProt ID CSK21_HUMAN
References
1 Novel non-ATP competitive small molecules targeting the CK2 / interface. Bioorg Med Chem. 2018 Jul 15; 26(11):3016-3020.

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