Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET0EX0V) | |||||
|---|---|---|---|---|---|
| Name |
Carbonic anhydrase (CA)
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| Family | Lyase/isomerase/ligase (L/I/G) >> Carbon-oxygen lyase (EC 4.2) | ||||
| Organism |
Homo sapiens (Human)
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| UniProt ID | CAH1_HUMAN | (click to find more protein-related data of this DBT) | |||
| CAH2_HUMAN | (click to find more protein-related data of this DBT) | ||||
| CAH3_HUMAN | (click to find more protein-related data of this DBT) | ||||
| CAH4_HUMAN | (click to find more protein-related data of this DBT) | ||||
| CAH5A_HUMAN | (click to find more protein-related data of this DBT) | ||||
| CAH5B_HUMAN | (click to find more protein-related data of this DBT) | ||||
| CAH7_HUMAN | (click to find more protein-related data of this DBT) | ||||
| CAH8_HUMAN | (click to find more protein-related data of this DBT) | ||||
| CAH9_HUMAN | (click to find more protein-related data of this DBT) | ||||
| CAH10_HUMAN | (click to find more protein-related data of this DBT) | ||||
| CAH11_HUMAN | (click to find more protein-related data of this DBT) | ||||
| CAH12_HUMAN | (click to find more protein-related data of this DBT) | ||||
| CAH13_HUMAN | (click to find more protein-related data of this DBT) | ||||
| CAH14_HUMAN | (click to find more protein-related data of this DBT) | ||||
| TTD ID | T43920 | (click to find more therapeutic target data of this DBT) | |||
| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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| DIG Name: Benzenesulfonic acid | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Acidulant
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 2000 nM (estimated based on the structural similarity with CHEMBL27601 ) | [1] | ||||
| Structural Similarity | Tanimoto coefficient = 0.890625 | |||||
| Tested Species | Homo sapiens (Human) | |||||
| UniProt ID | CAH1_HUMAN ; CAH2_HUMAN ; CAH3_HUMAN ; CAH4_HUMAN ; CAH5A_HUMAN ; CAH5B_HUMAN ; CAH7_HUMAN ; CAH8_HUMAN ; CAH9_HUMAN ; CAH10_HUMAN ; CAH11_HUMAN ; CAH12_HUMAN ; CAH13_HUMAN ; CAH14_HUMAN | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | Sulfonylmethanesulfonamide inhibitors of carbonic anhydrase. J Med Chem. 1993 Jul 23; 36(15):2134-41. | ||||
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