Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0F0PP)
Name
P2Y purinoceptor 2 (P2RY2)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Adenosine P2Y2 receptor; P2RY2; P2U nucleotide receptor; P2U purinoceptor 1; P2U receptor; P2U receptor 1; P2U1; P2Y2; ATP receptor; Purinergic receptor
Family G-protein coupled receptor (GPCR)  >>  G-protein coupled rhodopsin receptor (GPCR-A)
Organism
Homo sapiens (Human)
Gene Name P2RY2 Gene ID
5029
UniProt ID P2RY2_HUMAN (click to find more protein-related data of this DBT)
TTD ID T93515 (click to find more therapeutic target data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLC
RLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCS
ILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGR
VTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAK
RKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSC
LDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSR
RTESTPAGSENTKDIRL
Function
Receptor for ATP and UTP coupled to G-proteins thatactivate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: D&C green no. 5 Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Colorant
             Experiment (1) for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 3930 nM (estimated based on the structural similarity with CHEMBL401859 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.934131737
                   Tested Species Homo sapiens (Human)
                   UniProt ID P2RY2_HUMAN
             Experiment (2) for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 30000 nM (estimated based on the structural similarity with CHEMBL401859 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.934131737
                   Tested Species Mus musculus (Mouse)
                   UniProt ID P2RY2_MOUSE
References
1 Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists. Bioorg Med Chem Lett. 2008 Jan 1; 18(1):223-7.

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