Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0I4YO)
Name
Glutamate receptor NMDA (GRIN)
Family Transmembrane channel/porin (TC/P)  >>  Glutamate-gated ion channel (GIC)
Organism
Homo sapiens (Human)
UniProt ID NMDZ1_HUMAN (click to find more protein-related data of this DBT)
NMDE1_HUMAN (click to find more protein-related data of this DBT)
NMDE2_HUMAN (click to find more protein-related data of this DBT)
NMDE3_HUMAN (click to find more protein-related data of this DBT)
NMDE4_HUMAN (click to find more protein-related data of this DBT)
NMD3A_HUMAN (click to find more protein-related data of this DBT)
NMD3B_HUMAN (click to find more protein-related data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Aminoethanoic acid Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Buffering agent; Disintegrant; Lyophilization aid
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity Ki = 125.89 nM (tested by experiment) [1]
                   Tested Species Rattus norvegicus (Rat)
                   UniProt ID NMDZ1_RAT ; NMDE1_RAT ; NMDE2_RAT ; NMDE3_RAT ; NMDE4_RAT ; NMD3A_RAT ; NMD3B_RAT
          DIG Name: Glutamic acid hydrochloride Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Acidulant
             Experiment (1) for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 70 nM (estimated based on the structural similarity with CHEMBL575060 ) [2]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   UniProt ID NMDZ1_HUMAN ; NMDE1_HUMAN ; NMDE2_HUMAN ; NMDE3_HUMAN ; NMDE4_HUMAN ; NMD3A_HUMAN ; NMD3B_HUMAN
             Experiment (2) for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 69 nM (estimated based on the structural similarity with CHEMBL575060 ) [3]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Rattus norvegicus (Rat)
                   UniProt ID NMDZ1_RAT ; NMDE1_RAT ; NMDE2_RAT ; NMDE3_RAT ; NMDE4_RAT ; NMD3A_RAT ; NMD3B_RAT
          DIG Name: Glycine hydrochloride Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Buffering agent; Disintegrant; Lyophilization aid
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity EC50 = 68 nM (estimated based on the structural similarity with CHEMBL773 ) [4]
                   Structural Similarity Tanimoto coefficient = 0.964285714
                   Tested Species Rattus norvegicus (Rat)
                   UniProt ID NMDZ1_RAT ; NMDE1_RAT ; NMDE2_RAT ; NMDE3_RAT ; NMDE4_RAT ; NMD3A_RAT ; NMD3B_RAT
References
1 Drug design, in vitro pharmacology, and structure-activity relationships of 3-acylamino-2-aminopropionic acid derivatives, a novel class of partial agonists at the glycine site on the N-methyl-D-aspartate (NMDA) receptor complex. J Med Chem. 2009 Aug 27; 52(16):5093-107.
2 Synopsis of some recent tactical application of bioisosteres in drug design. J Med Chem. 2011 Apr 28; 54(8):2529-91.
3 Isolations of N-methyl-D-aspartic acid-type glutamate receptor ligands from Micronesian sponges. J Nat Prod. 2003 Jun; 66(6):784-7.
4 Design, synthesis and structure-activity relationships of novel strychnine-insensitive glycine receptor ligands. Bioorg Med Chem Lett. 1999 May 17; 9(10):1409-14.

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