Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0P5JZ)
Name
Leukemia HL-60 cells (HL-60)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Human acute myeloid leukemia HL-60 cells; HL 60; HL.60 HL60
Family Cell line (CELL)  >>  Blood cell line (BLOcel)
Organism
Homo sapiens (Human)
Cellosaurus ID CVCL_0002 (click to find more cell line data of this DBT)
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Calcium ascorbate anhydrous Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antioxidant
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 10 nM (estimated based on the structural similarity with CHEMBL196 ) [1]
                   Structural Similarity Tanimoto coefficient = 1
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0002
          DIG Name: Methyl cinnamate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Flavoring agent
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 35690 nM (estimated based on the structural similarity with CHEMBL318196 ) [2]
                   Structural Similarity Tanimoto coefficient = 0.972972973
                   Tested Species Homo sapiens (Human)
                   Cellosaurus ID CVCL_0002
References
1 Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. J Nat Prod. 2009 Jun; 72(6):983-7.
2 Phytochemical investigation of labdane diterpenes from the rhizomes of Hedychium spicatum and their cytotoxic activity. Bioorg Med Chem Lett. 2009 Nov 1; 19(21):6078-81.

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