Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0V5KB)
Name	Organic anion transporter 6 (OAT6)
Synonyms	Click to Show/Hide the Synonyms of This DBT Solute carrier family 22 member 20; Solute carrier family 22 member 20 pseudogene; SLC22A20; SLC22A20P
Family	Potential-driven transporter (PDT) >> Major facilitator (MF)
Organism	Homo sapiens (Human)
Gene Name	SLC22A20P		Gene ID	440044
UniProt ID	S22AK_HUMAN	(click to find more protein-related data of this DBT)
VARIDT ID	DTD0145	(click to find more drug transporter data of this DBT)
	Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence	MAFTDLLDALGSMGRFQLNHTALLLLPCGLLACHNFLQNFTAAVPPHHCRGPANHTEAST NDSGAWLRATIPLDQLGAPEPCRRFTKPQWALLSPNSSIPGAATEGCKDGWVYNRSVFPS TIVMEWDLVCEARTLRDLAQSVYMAGVLVGAAVFGSLADRLGCKGPLVWSYLQLAASGAA TAYFSSFSAYCVFRFLMGMTFSGIILNSVSLVVEWMPTRGRTVAGILLGYSFTLGQLILA GVAYLIRPWRCLQFAISAPFLIFFLYSWWLPESSRWLLLHGKSQLAVQNLQKVAAMNGRK EEGERLTKEVMSSYIQSEFASVCTSNSILDLFRTPAIRKVTCCLMVIWFSNSVAYYGLAM DLQKFGLSLYLVQALFGIINTPAMLVATATMIYVGRRATVASFLILAGLMVIANMFVPEG TQILCTAQAALGKGCLASSFICVYLFTGELYPTEIRQMGMGFASVHARLGGLTAPLVTTL GEYSTILPPVSFGATAILAGLAVCVLTETRNMPLVETIAAMERRVKEGSSKKHVEEKSEE ISLQQLRASPLKETI
Function	Organic anion transporter that mediates the uptake of estrone sulfate. Inhibited by probenecid, propionate, 2-methylbutyrate, 3-methylbutyrate, benzoate, heptanoate and 2-ethylhaxanoate. May act as an odorant transporter.

Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
DIG Name: Benzoic acid		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Antimicrobial preservative
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	Ki = 13800 nM (tested by experiment)		[1]
Tested Species	Mus musculus (Mouse)
UniProt ID	S22AK_MOUSE
DIG Name: D&C red no. 22		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Colorant
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	Ki = 4365.16 nM (estimated based on the structural similarity with CHEMBL376503 )		[1]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Mus musculus (Mouse)
UniProt ID	S22AK_MOUSE
DIG Name: Sodium stearate		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Emulsifying agent; Gelling agent; Glidant; Modified-release agent; Stiffening agent; lubricant
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	Ki = 8128.31 nM (estimated based on the structural similarity with CHEMBL320358 )		[1]
Structural Similarity	Tanimoto coefficient = 1
Tested Species	Mus musculus (Mouse)
UniProt ID	S22AK_MOUSE
DIG Name: Propionic acid		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Acidulant; Antimicrobial preservative; Antioxidant
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	Ki = 279000 nM (tested by experiment)		[1]
Tested Species	Mus musculus (Mouse)
UniProt ID	S22AK_MOUSE

References
1	Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members. J Biol Chem. 2007 Aug 17; 282(33):23841-53.

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