Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0W2VU)
Name	P2Y purinoceptor 4 (P2RY4)
Synonyms	Click to Show/Hide the Synonyms of This DBT Uridine nucleotide receptor; NRU; P2P; P2Y4; UNR
Family	G-protein coupled receptor (GPCR) >> G-protein coupled rhodopsin receptor (GPCR-A)
Organism	Homo sapiens (Human)
Gene Name	P2RY4		Gene ID	5030
UniProt ID	P2RY4_HUMAN	(click to find more protein-related data of this DBT)
TTD ID	T82083	(click to find more therapeutic target data of this DBT)
	Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence	MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLF IFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLY CSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKG TTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSR LRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSC LDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTP RADRL
Function	Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.

Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
DIG Name: D&C green no. 5		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Colorant
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	IC50 = 1910 nM (estimated based on the structural similarity with CHEMBL401859 )		[1]
Structural Similarity	Tanimoto coefficient = 0.934131737
Tested Species	Homo sapiens (Human)
UniProt ID	P2RY4_HUMAN

References
1	Development of Potent and Selective Antagonists for the UTP-Activated P2Y 4 Receptor. J Med Chem. 2017 Apr 13; 60(7):3020-3038.

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