Details of the Biological Target of DIG (DBT)
| General Information of DBT (ID: ET0W8VG) | |||||
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| Name |
Phosphodiesterase 1 (PDE1)
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| Family | Hydrolase (HDase) >> Ester bond hydrolase (EC 3.1) | ||||
| Organism |
Homo sapiens (Human)
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| UniProt ID | PDE1B_HUMAN | (click to find more protein-related data of this DBT) | |||
| PDE1C_HUMAN | (click to find more protein-related data of this DBT) | ||||
| TTD ID | T56367 | (click to find more therapeutic target data of this DBT) | |||
| Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT | ||||||
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| DIG Name: Caffeine | Click to Show/Hide | |||||
| Detailed Information |
DIG Info
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| Functional Class | Click to Show/Hide the Functional Class of This DIG
Other agent
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| Experiment for Assessing the Biological Activity of This DIG on the Studied DBT | ||||||
| Biological Activity | IC50 = 70000 nM (tested by experiment) | [1] | ||||
| Tested Species | Rattus norvegicus (Rat) | |||||
| UniProt ID | PDE1B_RAT ; PDE1C_RAT | |||||
| References | |||||
|---|---|---|---|---|---|
| 1 | 4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants. J Med Chem. 1990 Aug; 33(8):2240-54. | ||||
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