Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0XE1S)
Name
Gamma-BBH hydroxylase (BBOX1)
Synonyms    Click to Show/Hide the Synonyms of This DBT
Gamma-butyrobetaine dioxygenase; Gamma-butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine,2-oxoglutarate dioxygenase
Family Oxidoreductase (ORase)  >>  Oxygen paired donor oxidoreductase (EC 1.14)
Organism
Homo sapiens (Human)
Gene Name BBOX1 Gene ID
8424
UniProt ID BODG_HUMAN (click to find more protein-related data of this DBT)
   Click to Show/Hide the Molecular/Function Data (Sequence/Function) of This Target
Sequence
MACTIQKAEALDGAHLMQILWYDEEESLYPAVWLRDNCPCSDCYLDSAKARKLLVEALDV
NIGIKGLIFDRKKVYITWPDEHYSEFQADWLKKRCFSKQARAKLQRELFFPECQYWGSEL
QLPTLDFEDVLRYDEHAYKWLSTLKKVGIVRLTGASDKPGEVSKLGKRMGFLYLTFYGHT
WQVQDKIDANNVAYTTGKLSFHTDYPALHHPPGVQLLHCIKQTVTGGDSEIVDGFNVCQK
LKKNNPQAFQILSSTFVDFTDIGVDYCDFSVQSKHKIIELDDKGQVVRINFNNATRDTIF
DVPVERVQPFYAALKEFVDLMNSKESKFTFKMNPGDVITFDNWRLLHGRRSYEAGTEISR
HLEGAYADWDVVMSRLRILRQRVENGN
Function
Catalyzes the formation of L-carnitine from gamma-butyrobetaine.
Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
          DIG Name: Phenylmercuric acetate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 2600 nM (estimated based on the structural similarity with CHEMBL39469 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.766666667
                   Tested Species Homo sapiens (Human)
                   UniProt ID BODG_HUMAN
          DIG Name: Phenylmercuric borate Click to Show/Hide
             Detailed Information DIG Info click to show the detail info of this DIG
             Functional Class    Click to Show/Hide the Functional Class of This DIG
Antimicrobial preservative
             Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
                   Biological Activity IC50 = 39000 nM (estimated based on the structural similarity with CHEMBL3122204 ) [1]
                   Structural Similarity Tanimoto coefficient = 0.844827586
                   Tested Species Homo sapiens (Human)
                   UniProt ID BODG_HUMAN
References
1 Ejection of structural zinc leads to inhibition of -butyrobetaine hydroxylase. Bioorg Med Chem Lett. 2014 Nov 1; 24(21):4954-7.

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