Details of the Biological Target of DIG (DBT)

General Information of DBT (ID: ET0Y0QK)
Name	Prostate cancer LNCaP cells (LNCaP)
Synonyms	Click to Show/Hide the Synonyms of This DBT Human prostate carcinoma LNCaP cells; LNCAP; LNCap; Ln-Cap; Lymph Node Carcinoma of the prostate
Family	Cell line (CELL) >> Prostate cell line (PROcel)
Organism	Homo sapiens (Human)
Cellosaurus ID	CVCL_0395	(click to find more cell line data of this DBT)

Full List of Drug Inactive Ingredients (DIGs) Regulating This DBT
DIG Name: Glyceryl monostearate		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Emollient; Emulsifying agent; Emulsion stabilizing agent; Solubilizing agent; Surfactant; Viscosity-controlling agent
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	IC50 > 100000 nM (tested by experiment)		[1]
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0395
DIG Name: Tocopheryl acetate		Click to Show/Hide
Detailed Information	DIG Info click to show the detail info of this DIG
Functional Class	Click to Show/Hide the Functional Class of This DIG Antioxidant
Experiment for Assessing the Biological Activity of This DIG on the Studied DBT
Biological Activity	EC50 = 38000 nM (estimated based on the structural similarity with CHEMBL242495 )		[2]
Structural Similarity	Tanimoto coefficient = 0.933333333
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0395

References
1	Lignanamides and nonalkaloidal components of Hyoscyamus niger seeds. J Nat Prod. 2002 Feb; 65(2):206-9.
2	First pharmacophore-based identification of androgen receptor down-regulating agents: discovery of potent anti-prostate cancer agents. Bioorg Med Chem. 2007 May 15; 15(10):3413-21.

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