General Information of DFM (ID: F17614)
Name	Prasugrel 10 mg tablet
Company	Cardinal Health
Active Pharmaceutical Ingredient (API)	Prasugrel		API Info click to show the detail info of this API
	Myocardial infarction		ICD-11: BA41	Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0SJ4H	DIG Info	Beta-D-lactose	Diluent ...
	E09YYN	DIG Info	Eisenoxyd	Colorant
	E0M0IE	DIG Info	Ferric hydroxide oxide yellow	Colorant
	E0EI2M	DIG Info	Glyceryl dibehenate	Binding agent ...
	E0Q6DQ	DIG Info	Mannitol	Diluent ...
	E0I8GZ	DIG Info	Sucrose stearate	Dispersing agent ...
	E05BSD	DIG Info	Titanium dioxide	Coating agent ...
	E0T2AJ	DIG Info	Triacetin	Humectant ...

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Oxidoreductase (ORase)
DBT Name: Cytochrome P450 2E1 (CYP2E1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sucrose stearate
Biological Activity	EC50 = 173.9 uM (tested by experiment)					[1]
Tested Species	Homo sapiens (Human)
UniProt ID	CP2E1_HUMAN
Transmembrane channel/porin (TC/P)
DBT Name: Glycine receptor alpha-1 (GLRA1)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Mannitol
Biological Activity	EC50 = 12589.25 nM (estimated based on the structural similarity with CHEMBL604608 )					[2]
Structural Similarity	Tanimoto coefficient = 0.804878049
Tested Species	Homo sapiens (Human)
UniProt ID	GLRA1_HUMAN
Cell line (CELL)
DBT Name: Lung cancer A-549 cells (A-549)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Sucrose stearate
Biological Activity	IC50 = 0.63 ug.mL-1 (estimated based on the structural similarity with CHEMBL552345 )					[3]
Structural Similarity	Tanimoto coefficient = 0.940298507
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_0023

References
1	Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
2	Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective. Bioorg Med Chem Lett. 2017 Jun 1; 27(11):2239-2258.
3	Total synthesis and anticancer activity of highly potent novel glycolipid derivatives. Eur J Med Chem. 2009 Aug; 44(8):3120-9.

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