General Information of DFM (ID: F23223)
Name	Malathion 0.5% lotion
Company	Taro Pharm Inds Ltd
Active Pharmaceutical Ingredient (API)	Malathion		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0F7XM	DIG Info	Alpha-terpineol	Antioxidant ...
	E0N2PK	DIG Info	Isopropyl alcohol	Antimicrobial preservative ...
	E0QA5A	DIG Info	Limonene	Flavoring agent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Cell line (CELL)
DBT Name: Leukemia AML cells (AML193)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Alpha-terpineol
Biological Activity	IC50 = 14000 nM (estimated based on the structural similarity with CHEMBL1096927 )					[1]
Structural Similarity	Tanimoto coefficient = 0.978723404
Tested Species	Homo sapiens (Human)
Cellosaurus ID	CVCL_1071
DBT Name: Lymphoma P388/ADR cells (P388/ADR)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Isopropyl alcohol
Biological Activity	IC50 = 0.22 uM (estimated based on the structural similarity with CHEMBL545 )					[2]
Structural Similarity	Tanimoto coefficient = 0.789473684
Tested Species	Mus musculus (Mouse)
Cellosaurus ID	CVCL_IZ75

References
1	Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus. Eur J Med Chem. 2018 Sep 5; 157:198-228.
2	Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoprotein. J Med Chem. 2004 Mar 11; 47(6):1413-22.

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