Details of the Drug Formulation (DFM)

General Information of DFM (ID: F23622)
Name
Amikacin eq 250mg injectable
Company
Heritage Pharmaceuticals D/B/A Avet Pharmaceuticals
Active Pharmaceutical Ingredient (API) Amikacin API Info click to show the detail info of this API
Approved
Drug Inactive Ingredient (DIGs)
DIG ID DIG Info DIG Name DIG Functional Class
E0M5SQ DIG Info Sodium citrate anhydrous Alkalizing agent ...
E0E9LJ DIG Info Sodium metabisulfite Antimicrobial preservative ...
E0NV2K DIG Info Sulfuric acid Acidulant
Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
      Lyase/isomerase/ligase (L/I/G)
            DBT Name: Carbonic anhydrase IV (CA4) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Sodium citrate anhydrous
                    Biological Activity Ki = 99 nM (tested by experiment) [1]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH4_HUMAN
            DBT Name: Carbonic anhydrase V (CA5) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Interacting DIG Sulfuric acid
                    Biological Activity Ki = 680 nM (tested by experiment) [2]
                    Tested Species Homo sapiens (Human)
                    UniProt ID CAH5A_HUMAN ; CAH5B_HUMAN
References
1 Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with carboxylates. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):573-8.
2 Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions. Bioorg Med Chem Lett. 2004 Nov 1; 14(21):5435-9.

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