General Information of DFM (ID: F23922)
Name	Tromethamine 15.75mg spray
Company	Zyla Life Sciences Us
Active Pharmaceutical Ingredient (API)	Tromethamine		API Info click to show the detail info of this API
				Approved
Drug Inactive Ingredient (DIGs)
	DIG ID	DIG Info	DIG Name	DIG Functional Class
	E0FY2S	DIG Info	Edetate disodium	Complexing agent
	E0V4HH	DIG Info	Potassium phosphate monobasic	Buffering agent
	E0L2PN	DIG Info	Sodium hydroxide	Alkalizing agent
	E0H2SC	DIG Info	Water	Solvent

Full List of Biological Targets of DIG (DBTs) Regulated by DIG(s) in This DFM
Hydrolase (HDase)
DBT Name: Intestinal alkaline phosphatase (IAP)				Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Interacting DIG	Potassium phosphate monobasic
Biological Activity	IC50 = 2410 nM (tested by experiment)					[1]
Tested Species	Bos taurus (Bovine)
UniProt ID	PPBI_BOVIN

References
1	Synthesis, crystal structure and biological evaluation of some novel 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines. Eur J Med Chem. 2014 May 6; 78:167-77.

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