Details of the Drug Inactive Ingredient (DIG) | ACDINA

General Information of DIG (ID: E0DS2Q)
DIG Name	Meglumine
Synonyms	Click to Show/Hide the Synonyms of This DIG meglumine; N-Methyl-D-glucamine; 6284-40-8; N-Methylglucamine; Meglumin; 1-Deoxy-1-(methylamino)-D-glucitol; Meglumina; 1-Deoxy-1-methylaminosorbitol; D-Glucitol, 1-deoxy-1-(methylamino)-; (2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentaol; N-Methyl-D(-)-glucamine; N-Methylsorbitylamine; Megluminum; Methylglucamin; Megluminum [INN-Latin]; UNII-6HG8UB2MUY; Meglumina [INN-Spanish]; (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol; Sorbitol, 1-deoxy-1-methylamino-; MFCD00004707; 6HG8UB2MUY; CHEBI:59732; D-1-Deoxy-1-(methylamino)glucitol; NSC 7391; NSC 52907; DSSTox_CID_3244; DSSTox_RID_76939; DSSTox_GSID_23244; C7H17NO5; n-methyl-d-glucamine, 99%; EINECS 228-506-9; N-Methylglucamine solution; NSC-7391; NSC52907; NSC-52907; Meglumine [USP:INN:BAN:JAN]; N-methyl-glucamine; N-Methyl glucamine; NCGC00166125-01; CAS-6284-40-8; N-Methylglucamine solution (70% or less); EC 228-506-9; SCHEMBL2193; ARONIS27014; BIDD:GT0676; Meglumine (JP17/USP/INN); CHEMBL1200570; DTXSID0023244; 1-deoxy-1-(methylamino)-glucitol; 1-Methylamino-1-deoxy-D-glucitol; HMS2089B05; HMS3714B10; Pharmakon1600-01300029; EBD71934; HY-B0342; ZINC2020259; Tox21_112330; Tox21_302037; NSC759607; s1974; AKOS005167162; AKOS015850890; N-methyl-1-amino-1-deoxy-D-glucitol; Tox21_112330_1; AC-4692; CCG-220884; NSC-759607; NCGC00166125-02; NCGC00255365-01; AC-17087; AS-12002; SBI-0206683.P002; AB0011121; Meglumine, meets USP testing specifications; AM20100540; M0227; SW199350-2; D01796; AB00430469-03; AB00430469_05; Glucitol, 1-deoxy-1-(methylamino)-, D- (8CI); Q288875; SR-05000001446; N-Methyl-D-glucamine, 99.0-100.5% (titration); SR-05000001446-1; BRD-K28595280-001-01-1; N-Methyl-D-glucamine, Vetec(TM) reagent grade, 99%; N-Methyl-D-glucamine, ReagentPlus(R), >=99.0% (T); (2R,3R,4R,5S)-6-methylamino-hexane-1,2,3,4,5-pentaol; Meglumine, United States Pharmacopeia (USP) Reference Standard; N-methyl-(2 (S),3 (R),4 (R),5 (R),6-pentahydroxy-hexyl)-amine; Meglumine, Pharmaceutical Secondary Standard; Certified Reference Material; N-Methyl-D-glucamine, European Pharmacopoeia (EP) Reference Standard
DIG Function	Buffering agent
PubChem CID	8567
Formula	C7H17NO5
Canonical SMILES	CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
InChI	1S/C7H17NO5/c1-8-2-4(10)6(12)7(13)5(11)3-9/h4-13H,2-3H2,1H3/t4-,5+,6+,7+/m0/s1
InChIKey	MBBZMMPHUWSWHV-BDVNFPICSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=8567"></iframe>
Structure	3D MOL			2D MOL
Physicochemical Properties	Molecular Weight		195.21	Topological Polar Surface Area	113
	XlogP		-2.8	Complexity	134
	Heavy Atom Count		13	Rotatable Bond Count	6
	Hydrogen Bond Donor Count		6	Hydrogen Bond Acceptor Count	6

Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
ICD Disease Classification 01			Infectious/parasitic disease		Click to Show/Hide
Delafloxacin		API Info	Methicillin-resistant staphylococcus infection [ICD-11: 1D01]			[1]
ICD Disease Classification 05			Endocrine/nutritional/metabolic disease		Click to Show/Hide
Pravastatin		API Info	Dyslipidaemia [ICD-11: 5C81]			[2]
Rosuvastatin		API Info	Hypertriglyceridaemia [ICD-11: 5C80]			[3]
Repaglinide		API Info	Diabetes mellitus [ICD-11: 5A10]			[4]
ICD Disease Classification 08			Nervous system disease		Click to Show/Hide
Oxcarbazepine		API Info	Epilepsy [ICD-11: 8A60]			[5]
ICD Disease Classification 11			Circulatory system disease		Click to Show/Hide
Ramipril		API Info	Essential hypertension [ICD-11: BA00]			[6]
Telmisartan		API Info	Essential hypertension [ICD-11: BA00]			[7]
ICD Disease Classification 12			Respiratory system disease		Click to Show/Hide
Desloratadine		API Info	Allergic rhinitis [ICD-11: CA08]			[8]
ICD Disease Classification 13			Digestive system disease		Click to Show/Hide
Omeprazole		API Info	Gastro-oesophageal reflux disease [ICD-11: DA22]			[9]
Lansoprazole		API Info	Duodenal ulcer [ICD-11: DA63]			[10]
Esomeprazole		API Info	Duodenal ulcer [ICD-11: DA63]			[11]

Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
Transferase (TFase)
DBT Name: Alglucerase (GBA)			Click to Show/Hide
Detailed Information	DBT Info click to show the detail info of this DBT
Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
Biological Activity	IC50 = 447000 nM (estimated based on the structural similarity with CHEMBL1933095 )				[12]
Structural Similarity	Tanimoto coefficient = 0.846153846
Tested Species	Bos taurus (Bovine)
UniProt ID	GLCM_BOVIN

References
1	FDA label for approved delafloxacin from the official website of the U.S. Food and Drug Administration.
2	FDA label for approved pravastatin from the official website of the U.S. Food and Drug Administration.
3	FDA label for approved rosuvastatin from the official website of the U.S. Food and Drug Administration.
4	FDA label for approved repaglinide from the official website of the U.S. Food and Drug Administration.
5	FDA label for approved oxcarbazepine from the official website of the U.S. Food and Drug Administration.
6	FDA label for approved ramipril from the official website of the U.S. Food and Drug Administration.
7	FDA label for approved telmisartan from the official website of the U.S. Food and Drug Administration.
8	FDA label for approved desloratadine from the official website of the U.S. Food and Drug Administration.
9	FDA label for approved omeprazole from the official website of the U.S. Food and Drug Administration.
10	FDA label for approved lansoprazole from the official website of the U.S. Food and Drug Administration.
11	FDA label for approved esomeprazole from the official website of the U.S. Food and Drug Administration.
12	Towards a stable noeuromycin analog with a D-manno configuration: synthesis and glycosidase inhibition of D-manno-like tri- and tetrahydroxylated azepanes. Bioorg Med Chem. 2012 Jan 15; 20(2):641-9.

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