Details of the Drug Inactive Ingredient (DIG)

General Information of DIG (ID: E0VX5C)
DIG Name
DL-alpha-tocopherol
Synonyms    Click to Show/Hide the Synonyms of This DIG
DL-ALPHA-TOCOPHEROL; 10191-41-0; VITAMIN E; alpha-tochopherol; all-rac-alpha-Tocopherol; UNII-7QWA1RIO01; 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydrochromen-6-ol; 7QWA1RIO01; CHEMBL49563; .alpha.-Tocopherol; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-; d-.alpha.-Tocopherol; Ephanyl; 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)chroman-6-ol; 6-Chromanol, 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-; 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol; Evitaminum; Profecundin; Syntopherol; Waynecomycin; Almefrol; Emipherol; Epsilan; Etamican; Tokopharm; Vascuals; Vitayonon; Etavit; Ilitia; Evion; alpha Tocopherol; Vitaplex E; Eprolin S; Spavit E; ido-E; Endo E; Vita E; Lan-E; Med-E; Antisterility vitamin; 1406-18-4; Vi-E; 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-ol; Tocopheroxy radical; Tocopheroxyl radical; alpha-Tocopherol, DL-; 3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-benzopyran-6-ol; (+-)-alpha-Tocopherol; SR-05000001813; CCRIS 5853; DL-Tocopherol; MFCD00072051; .alpha.-Tokoferol; .alpha. Tocopherol; DL-alpha tocopherol; EINECS 233-466-0; 5,8-Trimethyltocol; Vitamin E DL-alpha; Tocopherol (JP17); BRN 0094012; dl-.alpha.-Tocopherol; Spectrum_001195; DL-all-rac-A-Tocopherol; Spectrum2_000722; Spectrum3_001338; Spectrum4_001771; Spectrum5_000381; (??)-??-Tocopherol; DL-5,7,8-trimethyltocol; EC 233-466-0; SCHEMBL22303; BSPBio_003095; KBioGR_002282; KBioSS_001675; SPECTRUM310039; (all-R)-.alpha.-Tocopherol; 113085-06-6; 5-17-04-00168 (Beilstein Handbook Reference); DivK1c_000533; SPBio_000644; alpha-Tocopherol, >=95.5%; DTXSID8021355; SCHEMBL14315133; (.+-.)-Med-E; (.+/-.)-.alpha.-Tocopherol; CHEBI:93909; HMS501K15; HSDB 8261; KBio1_000533; KBio2_001675; KBio2_004243; KBio2_006811; KBio3_002315; (2R,8'R)-.alpha.-Tocopherol; DL-alpha-Tocopherol (Vitamin E); Vitamin E (DL-alpha-Tocopherol); NINDS_000533; HMS1923I03; HMS2091C11; Pharmakon1600-00310039; (2R,4'S,8'R)-; A-Tocopherol; (2R,4'S,8'S)-; A-Tocopherol; (2S,4'R,8'R)-; A-Tocopherol; (2S,4'R,8'S)-; A-Tocopherol; (2S,4'S,8'R)-; A-Tocopherol; (2S,4'S,8'S)-; A-Tocopherol; 78656-13-0; 79434-82-5; 79434-83-6; C29H50O2 (DL-alpha-tocopherol); NSC20812; NSC82623; BBL027614; BDBM50436220; CCG-40162; NSC-20812; NSC-82623; NSC755839; s6104; SBB057399; STL372809; all-rac-alpha-Tocopherol (Vitamin E); AKOS015960364; DB14476; HY-W020044; MCULE-4241435740; NSC-755839; SDCCGMLS-0066634.P001; 2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-ol; IDI1_000533; NCGC00095254-01; NCGC00095254-02; NCGC00095254-03; NCGC00095254-05; NCGC00095254-06; AC-10544; SY012869; SY057064; VS-08569; SBI-0051261.P003; AB0211519; ( inverted exclamation markA)-; A-Tocopherol; (+/-)-alpha-Tocopherol, analytical standard; CS-0031997; FT-0600386; FT-0624406; FT-0625430; FT-0696605; D02332; AB00051898_02; SR-05000001813-1; SR-05000001813-2; (+/-)-alpha-Tocopherol, synthetic, >=96% (HPLC); (+/-)-alpha-Tocopherol, tested according to Ph.Eur.; BRD-A82892199-001-01-7; Q27165663; (+/-)-alpha-Tocopherol, SAJ special grade, >=96.0%; F0001-2420; UNII-R0ZB2556P8 component GVJHHUAWPYXKBD-UHFFFAOYSA-N; 7A4513C3-131C-41D4-B6A0-7ED994AC2947; alpha-Tocopherol, British Pharmacopoeia (BP) Reference Standard; DL-alpha-Tocopherol (Vitamin E) 10 microg/mL in Acetonitrile; 2,5,7,8-Tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanol #; alpha-Tocopherol, European Pharmacopoeia (EP) Reference Standard; Alpha Tocopherol, United States Pharmacopeia (USP) Reference Standard; Alpha Tocopherol, Pharmaceutical Secondary Standard; Certified Reference Material; (+/-)-alpha-Tocopherol (Vitamin E) solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material; [It may consist of d- or dl-.alpha.-tocopherol (C29H50O2), d- or dl-.alpha.-tocopheryl acid succinate (C33H54O5), mixed tocopherols concentrate, or d-.alpha.-tocopheryl acetate concentrate.]; 16826-11-2; 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, radical ion(1+), (2R-(2R*(4R*,8R*)))-; 2H-1-Benzopyran-6-ol,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, [2R*(4R*,8R*)]-(.+-.)-; 2H-1-Benzopyran-6-ol,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-, [2R-[2R*(4R*,8R*)]]-
DIG Function
Antioxidant
PubChem CID
2116
Formula
C29H50O2
Canonical SMILES
CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C
InChI
1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
InChIKey
GVJHHUAWPYXKBD-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This DIG
Structure
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 430.7 Topological Polar Surface Area 29.5
XlogP 10.7 Complexity 503
Heavy Atom Count 31 Rotatable Bond Count 12
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 2
Full List of Active Pharmaceutical Ingredients (APIs) Co-administrated with This DIG
       ICD Disease Classification 04 Immune system disease Click to Show/Hide
Cetirizine
 API Info
Allergy [ICD-11: 4A80]
 [1]
       ICD Disease Classification 08 Nervous system disease Click to Show/Hide
Acetaminophen
 API Info
Anaesthesia [ICD-11: 8E22]
 [2]
Tapentadol
 API Info
Neuropathic pain [ICD-11: 8E43]
 [3]
       ICD Disease Classification 14 Skin disease Click to Show/Hide
Isotretinoin
 API Info
Acne vulgaris [ICD-11: ED80]
 [4]
       ICD Disease Classification 15 Musculoskeletal/connective-tissue disease Click to Show/Hide
Cyclosporin A
 API Info
Rheumatoid arthritis [ICD-11: FA20]
 [5]
Full List of Biological Targets of DIG (DBTs) Regulated by This DIG
      Hydrolase (HDase)
            DBT Name: Presenilin 1 (PSEN1) Click to Show/Hide
               Detailed Information DBT Info click to show the detail info of this DBT
               Experiment for Assessing the Biological Activity of the Studied DIG on This DBT
                    Biological Activity EC50 > 100000 nM (tested by experiment) [6]
                    Tested Species Homo sapiens (Human)
                    UniProt ID PSN1_HUMAN
References
1 FDA label for approved cetirizine from the official website of the U.S. Food and Drug Administration.
2 FDA label for approved acetaminophen from the official website of the U.S. Food and Drug Administration.
3 FDA label for approved tapentadol from the official website of the U.S. Food and Drug Administration.
4 FDA label for approved isotretinoin from the official website of the U.S. Food and Drug Administration.
5 FDA label for approved cyclosporin A from the official website of the U.S. Food and Drug Administration.
6 Membrane anchoring -secretase modulators with terpene-derived moieties. Bioorg Med Chem Lett. 2013 Jul 1; 23(13):3852-6.

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