Drug General Information
Drug ID	D0R3GC
Former ID	DNC006728
Drug Name	D-Phe-Arg-2-Nal-NHCH3
Indication	Discovery agent		Investigative	[528325]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Melanocortin-4 receptor	Target Info	Inhibitor	[528325]
	Melanocyte stimulating hormone receptor	Target Info	Inhibitor	[528325]
KEGG Pathway	Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
	Melanogenesis
Pathway Interaction Database	Syndecan-3-mediated signaling events
Reactome	Peptide ligand-binding receptors
	G alpha (s) signalling eventsR-HSA-375276:Peptide ligand-binding receptors
	G alpha (s) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
	GPCR downstream signaling
References
Ref 528325	J Med Chem. 2006 Jul 27;49(15):4745-61.Design, synthesis, and evaluation of proline and pyrrolidine based melanocortin receptor agonists. A conformationally restricted dipeptide mimic approach.
Ref 528325	J Med Chem. 2006 Jul 27;49(15):4745-61.Design, synthesis, and evaluation of proline and pyrrolidine based melanocortin receptor agonists. A conformationally restricted dipeptide mimic approach.

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