TTD | Drug: D0S2QI

Drug General Information
Drug ID	D0S2QI
Former ID	DNC000992
Drug Name	Naproxene
Drug Type	Small molecular drug
Indication	Pain; Endometriosis [ICD9: 338, 617.0,780; ICD10:N80, R52, G89]		Investigative	[536772]
Therapeutic Class	Analgesics
Structure		Download 2D MOL 3D MOL
Formula	C14H14O3
Canonical SMILES	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O
InChI	1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1
InChIKey	CMWTZPSULFXXJA-VIFPVBQESA-N
CAS Number	CAS 22204-53-1
PubChem Compound ID	156391
PubChem Substance ID	4682, 597410, 3248704, 7847186, 7980083, 8149438, 10252902, 10321400, 11112669, 11335417, 11360656, 11363871, 11366433, 11368995, 11371667, 11373736, 11377157, 11461628, 11466819, 11467939, 11484702, 11486597, 11488859, 11490330, 11491884, 11494791, 15172373, 15172374, 22391409, 24857178, 24870224, 24883816, 24897861, 25649496, 26527900, 26611833, 26679674, 26755231, 46232210, 46487915, 46505508, 47291026, 47588882, 47810639, 48334369, 48334370, 48426145, 49833549, 50025704, 50103854
SuperDrug ATC ID	G02CC02
SuperDrug CAS ID	cas=022204531
Target and Pathway
Target(s)	Prostaglandin G/H synthase 2	Target Info	Inhibitor	[536772]
BioCyc Pathway	Aspirin-triggered lipoxin biosynthesis
	Aspirin triggered resolvin D biosynthesis
	C20 prostanoid biosynthesis
	Aspirin triggered resolvin E biosynthesis
KEGG Pathway	Arachidonic acid metabolism
	Metabolic pathways
	NF-kappa B signaling pathway
	VEGF signaling pathway
	TNF signaling pathway
	Retrograde endocannabinoid signaling
	Serotonergic synapse
	Ovarian steroidogenesis
	Oxytocin signaling pathway
	Regulation of lipolysis in adipocytes
	Leishmaniasis
	Pathways in cancer
	Chemical carcinogenesis
	MicroRNAs in cancer
	Small cell lung cancer
NetPath Pathway	IL1 Signaling Pathway
	TSH Signaling Pathway
	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
	IL5 Signaling Pathway
PANTHER Pathway	Endothelin signaling pathway
	Inflammation mediated by chemokine and cytokine signaling pathway
	Toll receptor signaling pathway
	CCKR signaling map ST
Pathway Interaction Database	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
	S1P1 pathway
	C-MYB transcription factor network
	Signaling mediated by p38-alpha and p38-beta
	Calcium signaling in the CD4+ TCR pathway
PathWhiz Pathway	Arachidonic Acid Metabolism
WikiPathways	Prostaglandin Synthesis and Regulation
	Arachidonic acid metabolism
	Aryl Hydrocarbon Receptor
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Eicosanoid Synthesis
	Selenium Micronutrient Network
References
Ref 536772	New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202.
Ref 536772	New drugs in development for the treatment of endometriosis. Expert Opin Investig Drugs. 2008 Aug;17(8):1187-202.

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