TTD | Drug: D0OR2L

Drug General Information
Drug ID	D0OR2L
Former ID	DNC002624
Drug Name	Cholic Acid
Drug Type	Small molecular drug
Indication	Peroxisomal disorders; Synthesis disorders		Approved	[541327]
Structure		Download 2D MOL 3D MOL
Formula	C24H40O5
InChI	InChI=1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1
InChIKey	BHQCQFFYRZLCQQ-OELDTZBJSA-N
CAS Number	CAS 81-25-4
PubChem Compound ID	221493
PubChem Substance ID	3963, 72129, 584143, 607109, 822057, 841391, 3135999, 4266387, 7886587, 8145669, 9376190, 11110315, 14757556, 15277848, 17422064, 24423691, 24423929, 24892356, 24893153, 26717723, 26717726, 26717727, 26737120, 26737126, 26737128, 26750105, 26750407, 26750412, 26750415, 26750420, 26750424, 30424718, 46507063, 47193710, 47662491, 49700787, 50452100, 53787750, 53789207, 56313736, 56437567, 56437568, 57399957, 81067251, 81091088, 85279435, 85285851, 85285861, 85285865, 85285871
SuperDrug ATC ID	A05AA03
Target and Pathway
Target(s)	Phospholipase A2	Target Info	Inhibitor	[551393]
	Ferrochelatase	Target Info	Inhibitor	[551393]
	Liver carboxylesterase	Target Info	Inhibitor	[551393]
BioCyc Pathway	PhospholipasesPWY-5920:Heme biosynthesis
BioCyc Pathway	Heme biosynthesis from uroporphyrinogen-III I
KEGG Pathway	Glycerophospholipid metabolism
	Ether lipid metabolism
	Arachidonic acid metabolism
	Linoleic acid metabolism
	alpha-Linolenic acid metabolism
	Metabolic pathways
	Ras signaling pathway
	Vascular smooth muscle contraction
	Pancreatic secretion
	Fat digestion and absorptionhsa00860:Porphyrin and chlorophyll metabolism
	Metabolic pathwayshsa00983:Drug metabolism - other enzymes
PANTHER Pathway	Heme biosynthesis
Pathway Interaction Database	Fc-epsilon receptor I signaling in mast cellshif1_tfpathway:HIF-1-alpha transcription factor networke2f_pathway:E2F transcription factor network
PathWhiz Pathway	Porphyrin Metabolism
Reactome	Acyl chain remodelling of PC
	Acyl chain remodelling of PE
	Acyl chain remodelling of PI
WikiPathways	Glycerophospholipid biosynthesisWP561:Heme Biosynthesis
	Metabolism of porphyrinsWP2884:NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 541327	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 609).
Ref 551393	How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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