Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00030)
Name
Aminocaproic acid
Synonyms    Click to Show/Hide the Synonyms of This API
6-aminohexanoic acid; 6-Aminocaproic acid; aminocaproic acid; 60-32-2; amicar; Hexanoic acid, 6-amino-; Epsikapron; Capramol; Caprocid; Epsamon; EPSILON-AMINOCAPROIC ACID; Acepramin; Caprolisin; Epsicapron; Hemocaprol; Respramin; Amikar; Epsilcapramin; Acepramine; Aminokapron; Caplamin; Capracid; Afibrin; Atsemin; Hemopar; Ipsilon; Epsilon S; Aminocaproic; Capralense; epsilon-Leucine; omega-Aminocaproic acid; epsilcapramine; epsilon-Norleucine; 6-Amino-n-hexanoic acid; epsilon-Aminohexanoic acid; omega-Aminohexanoic acid; 6-amino-hexanoic acid; Capranol; Eaca kabi; epsilon-Amino-n-hexanoic acid; Epsilon-aminocapronzuur; Acido aminocaproico; Epsilon-Aminocapronsaeure; epsilon Aminocaproic Acid; Acidum aminocaproicum; CY 116; 6-aminohexanoate; Acide aminocaproique [French]; Acidum aminocaproicum [Latin]; CL 10304; CY-116; NSC-26154; epsilon-aminocaproate; Amicar (TN); 177 J.D.; Acido aminocaproico [DCIT,Spanish]; epsilon-Amino-n-caproic acid; MFCD00008238; Kyselina omega-aminokapronova [Czech]; .epsilon.-Aminocaproic acid; NSC 26154; HEXANOIC ACID,6-AMINO; 6-amino-n-caproic acid; .epsilon.-Norleucine; 6-amino caproic acid; epsilon-Aminocaproic acid (JAN); H-Acp-OH; UNII-U6F3787206; .omega.-Aminocaproic acid; 6-amino-n-caproate; 1319-82-0; .omega.-Aminohexanoic acid; 177 J.D; .epsilon.-Aminohexanoic acid; CHEBI:16586; .epsilon. S; .epsilon.-Leucine; NSC26154; NSC400230; NSC-400230; CAS-60-32-2; NCGC00015092-02; Caproamin; DSSTox_CID_70; U6F3787206; WLN: Z5VQ; DSSTox_RID_75347; DSSTox_GSID_20070; Acide aminocaproique; e-amino-n-caproic acid; e-Aminocaproic acid; 6-Aminocaproic acid, 99+%; Epsicaprom; epsilon-Ahx; acide aminocaproque; Kyselina omega-aminokapronova; JD 177; SMR000059162; Aminocaproic Acid In Plastic Container; CCRIS 7706; Hexanoic acid, amino-; HSDB 3005; Acide aminocaproique [INN-French]; Acido aminocaproico [INN-Spanish]; Acidum aminocaproicum [INN-Latin]; SR-01000075688; Aminocaproic acid (USP); Aminocaproic acid [USAN:BAN:INN]; EINECS 200-469-3; NSC 400230; BRN 0906872; Acikaprin; Epsilon; amino caproic; e-Aminocaproate; w-Aminocaproate; Aminocaproic acid (USP/INN); e-Norleucine; AI3-14512; e-Aminohexanoate; w-Aminohexanoate; 6-Aminocaproate; e-Leucine; epsilon-S; 6-amino-Hexanoate; 6Aminocaproic acid; omega-Aminocaproate; Amino Caproic Acid; trifluoroacctic acid; H-epsilon-Acp-OH; omega-Aminohexanoate; w-Aminocaproic acid; e-Amino-n-hexanoate; e-Aminohexanoic acid; w-Aminohexanoic acid; 6-Amino-n-hexanoate; epsilon-Aminohexanoate; Epsillon-Aminocaproate; H-EAhx-OH; Aminocaproic acid [USAN:USP:INN:BAN]; Spectrum_000038; CL-10304; ACMC-1AXZE; e-Amino-n-hexanoic acid; e-Aminocaproic acid USP; epsilon-Amino-n-hexanoate; H-6-Ahx-OH; Prestwick0_000960; Prestwick1_000960; Prestwick2_000960; Prestwick3_000960; Spectrum2_000131; Spectrum4_000143; Spectrum5_000780; Lopac-A-7824; Epsillon-Aminocaproic acid; epsilon-amino caproic acid; bmse000394; H-Acp(6)-OH; A 7824; Aminocaproic acid (Amicar); 6-Aminocaproic acid; EACA; _6-__-_Aminocaproic acid; CHEMBL1046; Lopac0_000082; SCHEMBL15293; BSPBio_000960; CBDivE_004370; KBioGR_000586; KBioSS_000398; A-?Aminocaproic acid; epsilon-Aminocaproic acid USP; MLS001335991; MLS002695931; BIDD:GT0162; DivK1c_000551; NH2-(CH2)5-COOH; SPECTRUM1500114; SPBio_000202; SPBio_003109; (6-)epsilon-Aminocaproic acid; BPBio1_001056; GTPL6574; .epsilon.-Amino-n-caproic acid; DTXSID0020070; .epsilon.-Amino-n-hexanoic acid; CHEBI:79212; HMS501L13; KBio1_000551; KBio2_000398; KBio2_002966; KBio2_005534; NINDS_000551; HMS1570P22; HMS1920C07; HMS2091I07; HMS2097P22; HMS2231F21; HMS3260A06; HMS3373F09; HMS3655M17; HMS3714P22; Pharmakon1600-01500114; ALBB-022460; BCP24729; BCP27495; EBD17973; HY-B0236; ZINC1529425; Tox21_110081; Tox21_500082; 177 JD; 177-JD; AC-035; ANW-33472; BBL007716; BDBM50357211; CCG-38935; LMFA01100035; NSC212532; NSC755867; SBB015068; STK246894; AKOS000118734; Tox21_110081_1; AM82438; DB00513; KS-5276; LP00082; MCULE-3640363033; NE10566; NSC-212532; NSC-755867; SDCCGSBI-0050070.P005; IDI1_000551; pound 6- pound(c); A-Aminocaproic acid; 6-Aminocaproic acid, BioUltra, >=99%; Epsillon-Aminocaproic acid' Epsilcapramin; NCGC00015092-01; NCGC00015092-03; NCGC00015092-04; NCGC00015092-05; NCGC00015092-06; NCGC00015092-07; NCGC00015092-09; NCGC00015092-10; NCGC00015092-17; NCGC00093587-01; NCGC00093587-02; NCGC00093587-03; NCGC00093587-04; NCGC00260767-01; 6-Aminohexanoic acid, >=98.5% (NT); AK144762; AMINOCAPROIC ACID (aminocaproic acid).; BP-20395; ST075413; SY003109; 6-Aminocaproic acid; 6-Aminohexanoic acid; SBI-0050070.P004; AB00051911; EU-0100082; FT-0620933; SW197248-3; A10065; A15677; C02378; D00160; AB00051911-08; AB00051911_09; AB00051911_10; 101172-EP2302382A2; 101172-EP2302383A2; 319A820; 6-Aminocaproic acid, >=99% (titration), powder; Q255968; 6-Aminocaproic acid, SAJ special grade, >=99.0%; SR-01000075688-1; SR-01000075688-3; SR-01000075688-6; EACA;Epsilon-Amino-n-caproic Acid;6-Aminohexanoic acid; F2191-0201; C3BDD377-8F43-4BEC-900A-D5850050BA82; Aminocaproic acid, European Pharmacopoeia (EP) Reference Standard; Aminocaproic acid, United States Pharmacopeia (USP) Reference Standard; Acepramine; 6-Amino-n-hexanoic Acid; 6-Aminocaproic Acid; 6-Aminohexanoic Acid
Clinical Status
Approved
Disease Indication Menorrhagia ICD-11: GA20 [1]
PubChem CID
564
Formula
C6H13NO2
Canonical SMILES
C(CCC(=O)O)CCN
InChI
1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9)
InChIKey
SLXKOJJOQWFEFD-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=564"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 131.17 Topological Polar Surface Area 63.3
XlogP -3 Complexity 83.1
Heavy Atom Count 9 Rotatable Bond Count 5
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Aminocaproic acid 1000 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Crospovidone; Povidone
                   Dosage Form Oral Tablet
                   Company Xanodyne Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Crospovidone; Povidones
                   Dosage Form Oral Tablet
                   Company Clover Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Crospovidone; Povidones
                   Dosage Form Oral Tablet
                   Company VersaPharm
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
          Aminocaproic acid 500 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Crospovidone; Povidone
                   Dosage Form Oral Tablet
                   Company Xanodyne Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Povidone DIG Info Cholesterol 25-hydroxylase (IC50 = 78.3 uM) [3]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Crospovidone; Povidones
                   Dosage Form Oral Tablet
                   Company Avera McKennan Hospital; Clover Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
Crospovidone DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Povidones
                   Dosage Form Oral Tablet
                   Company VersaPharm
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [4]
References
1 FDA label for approved aminocaproic acid from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Mediation of in vitro cytochrome p450 activity by common pharmaceutical excipients. Mol Pharm. 2013 Jul 1;10(7):2739-48.
4 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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