Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00085)
Name
Busulfan
Synonyms    Click to Show/Hide the Synonyms of This API
busulfan; 55-98-1; Myleran; Busulphan; Sulphabutin; Myelosan; Leucosulfan; Busulfex; Citosulfan; Mielucin; Misulban; Mitostan; Myeloleukon; Mylecytan; Sulfabutin; Mablin; Mielevcin; Milecitan; Mielosan; Mileran; butane-1,4-diyl dimethanesulfonate; Buzulfan; 1,4-Dimesyloxybutane; 1,4-BUTANEDIOL DIMETHANESULFONATE; Myeleukon; 1,4-Butanediol, dimethanesulfonate; 1,4-Dimethanesulfonoxybutane; Tetramethylene dimethane sulfonate; Busulfano; Busulfanum; Busulphane; 1,4-Dimethylsulfonyloxybutane; 1,4-Dimethanesulfonyloxybutane; 1,4-Bis(methanesulfonoxy)butane; 1,4-Butanediol dimethylsulfonate; 1,4-Dimethylsulfonoxybutane; 1,4-Bis(methanesulfonyloxy)butane; NCI-C01592; 4-methylsulfonyloxybutyl methanesulfonate; CB 2041; AN 33501; Methanesulfonic acid, tetramethylene ester; Tetramethylene bis(methanesulfonate); 1,4-Dimethanesulphonyloxybutane; NSC 750; NSC-750; 1,4-Butanediol dimethanesulphonate; Tetramethylenester kyseliny methansulfonove; C.B. 2041; GT 2041; Tetramethylene bis[methanesulfonate]; UNII-G1LN9045DK; NSC750; 1,4-Bis[methanesulfonoxy]butane; CHEBI:28901; 2041 C. B.; G.T. 41; G1LN9045DK; 4-(methanesulfonyloxy)butyl methanesulfonate; MFCD00007562; NCGC00090905-06; Busilvex; Mitosan; DSSTox_CID_910; Busulfanum [INN-Latin]; DSSTox_RID_75857; Busulfano [INN-Spanish]; DSSTox_GSID_20910; Methanesulfonic; C6H14O6S2; CAS-55-98-1; CCRIS 418; SR-01000765405; EINECS 200-250-2; BRN 1791786; Bisulfex; AI3-25012; Busulfan;; Busulfan/Myleran; Busulfan solution; Busulfex IV; Busulfan [USP:INN:BAN:JAN]; HSDB 7605; Tetramethylenester kyseliny methansulfonove [Czech]; Prestwick_989; ACMC-20aljs; Tetramethylene {bis[methanesulfonate]}; Spectrum_000092; 2041 C.B.; Spectrum2_000067; Spectrum3_000320; Spectrum4_000259; Spectrum5_000928; CHEMBL820; NCIMech_000192; SCHEMBL4373; WLN: WS1&O4OSW1; BSPBio_001920; KBioGR_000698; KBioSS_000512; MLS001076666; Busulfan (Myleran, Busulfex); DivK1c_000847; SPECTRUM1500152; Busulfan (JP17/USP/INN); SPBio_000253; GTPL7136; DTXSID3020910; COVZYZSDYWQREU-UHFFFAOYSA-; HMS502K09; KBio1_000847; KBio2_000512; KBio2_003080; KBio2_005648; KBio3_001420; NINDS_000847; HMS1920I07; HMS2091O09; HMS2233H04; HMS3259G15; HMS3370E11; HMS3655A21; HMS3712A20; Pharmakon1600-01500152; HY-B0245; ZINC1530572; Tox21_111038; Tox21_201848; Tox21_300318; 1, {4-Bis[methanesulfonoxy]butane}; 2041CB; AC-198; BDBM50237623; CCG-35458; NSC755916; AKOS003614975; Tox21_111038_1; DB01008; KS-5212; MCULE-1840882522; NC00498; NSC-755916; IDI1_000847; NCGC00090905-01; NCGC00090905-02; NCGC00090905-03; NCGC00090905-04; NCGC00090905-05; NCGC00090905-07; NCGC00090905-08; NCGC00090905-09; NCGC00090905-10; NCGC00090905-11; NCGC00090905-12; NCGC00254038-01; NCGC00259397-01; 4-(methylsulfonyloxy)butyl methylsulfonate; NCI60_041640; SMR000058613; SBI-0051300.P003; AB0006846; FT-0623291; FT-0663910; ST45022142; SW198555-3; C06862; D00248; K-9954; 15167-EP2272827A1; 15167-EP2272832A1; 15167-EP2275420A1; 15167-EP2295055A2; 15167-EP2295416A2; 15167-EP2295426A1; 15167-EP2295427A1; 15167-EP2298748A2; 15167-EP2298764A1; 15167-EP2298765A1; 15167-EP2298778A1; 15167-EP2305642A2; 15167-EP2308833A2; 15167-EP2308861A1; 15167-EP2311453A1; 15167-EP2311825A1; 15167-EP2311842A2; 15167-EP2316832A1; 15167-EP2316833A1; 32314-EP2280012A2; 32314-EP2281815A1; 32314-EP2292595A1; 32314-EP2292615A1; 32314-EP2301928A1; 32314-EP2301933A1; 32314-EP2305640A2; 32314-EP2305671A1; 32314-EP2311827A1; 32314-EP2311840A1; 4-[(Methylsulfonyl)oxy]butyl methanesulfonate #; AB00051929-10; AB00051929-11; AB00051929_12; AB00051929_14; Busulfan, analytical standard, for drug analysis; Q348922; SR-01000765405-2; SR-01000765405-3; SR-01000765405-7; Busulfan, European Pharmacopoeia (EP) Reference Standard; Z276508890
Clinical Status
Approved
Disease Indication Chronic myelogenous leukaemia ICD-11: 2A20 [1]
PubChem CID
2478
Formula
C6H14O6S2
Canonical SMILES
CS(=O)(=O)OCCCCOS(=O)(=O)C
InChI
1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3
InChIKey
COVZYZSDYWQREU-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2478"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 246.3 Topological Polar Surface Area 104
XlogP -0.5 Complexity 294
Heavy Atom Count 14 Rotatable Bond Count 7
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 6
Full List of Drug Formulations (DFMs) Containing This API
          Busulfan 2 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Titanium dioxide; Triacetin; Hypromelloses; Starch, corn
                   Dosage Form Oral Tablet
                   Company Aspen Global
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Titanium dioxide; Triacetin; Hypromelloses; Starch, corn
                   Dosage Form Oral Tablet
                   Company GlaxoSmithKline
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved busulfan from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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