Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00138)
Name
Clomifene
Synonyms    Click to Show/Hide the Synonyms of This API
clomiphene; Clomifene; Enclomifene; trans-Clomiphene; Enclomiphene; trans-Clomifene; Enclomiphene [USAN]; UNII-R6D2UI4FLS; Cisclomiphene; Transclomiphene; RMI 16,289; ISOMER B; R6D2UI4FLS; 15690-57-0; Androxal; Clomifeno; 911-45-5; Enclomiphene (USAN); Transclomifenum; 2-[4-[(E)-2-chloro-1,2-diphenylethenyl]phenoxy]-N,N-diethylethanamine; Clomifenum; Enclomifeno; Enclomifenum; Enclomifenum [INN-Latin]; Enclomifeno [INN-Spanish]; ICI 46476; CHEBI:3752; Chlomaphene; Chloramifene; Clomifen; RMI-16289; 2-{4-[(E)-2-chloro-1,2-diphenylethenyl]phenoxy}-N,N-diethylethanamine; Clomifene (TN); Clomifene (INN); NCGC00179503-02; Enclomifene [INN]; Clomiphene trans-form; ISOMER-B; (E)-2-(p-(2-Chloro-1,2-diphenylvinyl)phenoxy)triethylamine; trans-2-(p-(2-Chloro-1,2-diphenylvinyl)phenoxy)triethylamine; Prestwick2_000397; Prestwick3_000397; CHEMBL954; trans-2-(4-(2-Chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine; 2-(p-(beta-chloro-alpha-phenylstyryl)phenoxy)triethylamine; BSPBio_000613; MLS001304092; MLS006011852; BIDD:ER0223; BIDD:GT0216; {2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]ethyl}diethylamine; 2-(4-(2-Chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine; 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethylethanamine; BPBio1_000675; GTPL7619; BDBM55354; cid_1548953; cid_6420009; HMS2090O17; HMS2232E06; ZINC1530601; STK525981; Triethylamine, 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)-, (E)-; AKOS005459442; Ethanamine, 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-, (E)-; ACN-032043; DB06735; NCGC00179503-01; NCGC00179503-12; SMR000718756; SMR004703502; C06917; D07726; D08910; 911C455; BRD-K04218075-048-03-4; UNII-1HRS458QU2 component GKIRPKYJQBWNGO-OCEACIFDSA-N; 1-(p-.beta.-Diethylaminoethoxyphenyl)-1,2-diphenyl-2-chloroethylene; 1-[(E)-2-chloro-1,2-diphenylethenyl]-4-methoxybenzene; clomiphene; 2-[4-[(E)-2-chloro-1,2-di(phenyl)ethenyl]phenoxy]-N,N-diethylethanamine; 2-[4-[(E)-2-chloro-1,2-diphenyl-vinyl]phenoxy]-N,N-diethyl-ethanamine; 2-{4-[(E)-2-chloro-1,2-diphenylethenyl]phenoxy}-N,N-diethylethan-1-amine; ETHANAMINE, 2-[4-[(1E)-2-CHLORO-1,2-DIPHENYLETHENYL]PHENOXY]-N,N-DIETHYL
Clinical Status
Approved
Disease Indication Female infertility ICD-11: GA31 [1]
PubChem CID
1548953
Formula
C26H28ClNO
Canonical SMILES
CCN(CC)CCOC1=CC=C(C=C1)/C(=C(\\C2=CC=CC=C2)/Cl)/C3=CC=CC=C3
InChI
1S/C26H28ClNO/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23/h5-18H,3-4,19-20H2,1-2H3/b26-25+
InChIKey
GKIRPKYJQBWNGO-OCEACIFDSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=1548953"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 406 Topological Polar Surface Area 12.5
XlogP 7.2 Complexity 481
Heavy Atom Count 29 Rotatable Bond Count 9
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 2
Full List of Drug Formulations (DFMs) Containing This API
          Clomifene 50 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company EMD Serono; Teva Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Sucrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Sanofi-Aventis
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Sucrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company PD-Rx Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose; Magnesium stearate; Sucrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Watson Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Sucrose; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; NuCare Pharmaceuticals; Par Pharmaceutical; Physicians Total Care
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved clomifene from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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