Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00160)
Name
Cyproheptadine
Synonyms    Click to Show/Hide the Synonyms of This API
CYPROHEPTADINE; Periactin; 129-03-3; Eiproheptadine; Periactinol; Dronactin; 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine; Ciproheptadina; Cyproheptadinum; MK 141; 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine; 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine; 5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene; 1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine; 4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine; UNII-2YHB6175DO; CHEMBL516; Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-; 2YHB6175DO; CHEBI:4046; Cypoheptadine; Cyproheptadiene; Periactine; 4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine; Piperidine, 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methyl-; 1-Methyl-4-(5H-dibenzo[a,d]cycloheptenylidene)piperidine; NCGC00015252-08; DSSTox_CID_2872; 41354-29-4; DSSTox_RID_76768; DSSTox_GSID_22872; Cyproheptadine [INN:BAN]; Cyproheptadinum [INN-Latin]; 4-Dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine; Ciproheptadina [INN-Spanish]; Ciprovit (TN); CAS-129-03-3; CCRIS 5232; Cyproheptadine (INN); HSDB 3048; EINECS 204-928-9; BRN 1685976; cyproheptidine; Reactin; 4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene; Peritol (Salt/Mix); Tocris-0996; Prestwick0_000103; Prestwick1_000103; Prestwick2_000103; Prestwick3_000103; Lopac-C-6022; Biomol-NT_000131; SCHEMBL4021; Lopac0_000246; Oprea1_498140; BSPBio_000086; GTPL277; 5-20-08-00500 (Beilstein Handbook Reference); BIDD:GT0324; SPBio_002025; BPBio1_000096; BPBio1_000155; DTXSID8022872; HMS2090P20; ZINC968264; Tox21_110112; BBL010977; BDBM50017721; DL-136; MFCD00242817; PDSP1_001229; PDSP2_001213; STK802098; AKOS004119847; Tox21_110112_1; CCG-204341; DB00434; MCULE-3352282545; SDCCGSBI-0050234.P003; NCGC00015252-01; NCGC00015252-02; NCGC00015252-03; NCGC00015252-04; NCGC00015252-05; NCGC00015252-06; NCGC00015252-07; NCGC00015252-09; NCGC00015252-10; NCGC00015252-12; NCGC00015252-13; NCGC00015252-26; NCGC00024293-02; NCGC00024293-04; NCGC00024293-05; CAS-969-33-5; VS-02784; SBI-0050234.P002; DB-041917; FT-0631755; C06935; D07765; 16621-EP2281563A1; 16621-EP2295409A1; 16621-EP2314590A1; 16621-EP2316459A1; 129C033; L001016; Q417884; BRD-K28143534-001-01-4; BRD-K28143534-001-03-0; BRD-K28143534-003-03-6; BRD-K28143534-003-14-3; 4-(dibenzo[[?],[?]][7]annulen-11-ylidene)-1-methyl-piperidine; 4-(Dibenzo[1,2-A:2',1'-D][7]annulen-11-Ylidene)-1-Methyl-Piperidine
Clinical Status
Approved
Disease Indication Allergic rhinitis ICD-11: CA08 [1]
PubChem CID
2913
Formula
C21H21N
Canonical SMILES
CN1CCC(=C2C3=CC=CC=C3C=CC4=CC=CC=C42)CC1
InChI
1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3
InChIKey
JJCFRYNCJDLXIK-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2913"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 287.4 Topological Polar Surface Area 3.2
XlogP 4.7 Complexity 423
Heavy Atom Count 22 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 1
Full List of Drug Formulations (DFMs) Containing This API
          Cyproheptadine Hydrochloride 4mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Microcrystalline Cellulose; Lactose Monohydrate; Magnesium Stearate; Sodium Starch Glycolate Type A Potato
                   Dosage Form Tablet
                   Company Breckenridge Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose Monohydrate; Magnesium Stearate; Microcrystalline Cellulose; Sodium Starch Glycolate Type A Potato
                   Dosage Form Tablet
                   Company Avpak; Proficient Rx
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Cyproheptadine 4 mg tablet Click to Show/Hide the Full List of Formulation(s):          7 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a corn
                   Dosage Form Oral Tablet
                   Company Ingenus Pharmaceuticals; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company NCS HealthCare of KY, Inc dba Vangard Labs; RemedyRepack; State of Florida DOH Central Pharmacy; Teva Pharmaceuticals; Trigen Laboratories; TruPharma
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Starch, corn
                   Dosage Form Oral Tablet
                   Company CorePharma; Dash Pharmaceuticals; Physicians Total Care; RemedyRepack; State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Bryant Ranch Prepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Golden State Medical Supply
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company AvKARE; C.O. Truxton; Cadila Healthcare; Carilion Materials Management; Cypress Pharmaceutical; RemedyRepack; Zydus Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved cyproheptadine from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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