Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00256)
Name
Etidronic acid
Synonyms    Click to Show/Hide the Synonyms of This API
Etidronic acid; 2809-21-4; etidronate; 1-Hydroxyethylidene-1,1-diphosphonic acid; Etidronsaeure; Acetodiphosphonic acid; Hydroxyethanediphosphonic acid; Didronel; Turpinal SL; Oxyethylidenediphosphonic acid; Dequest 2015; Dequest Z 010; Acido etidronico; Ferrofos 510; Acide etidronique; 1-Hydroxyethane-1,1-diphosphonate; 1-Hydroxyethane-1,1-diphosphonic acid; Phosphonic acid, (1-hydroxyethylidene)bis-; Diphosphonate (base); (1-Hydroxyethane-1,1-diyl)diphosphonic acid; 1-Hydroxyethanediphosphonic acid; Dequest 2010; Ethane-1-hydroxy-1,1-diphosphonic acid; (Hydroxyethylidene)diphosphonic acid; Ethane-1-hydroxy-1,1-diphosphonate; (1-Hydroxyethylene)diphosphonic acid; Acide etidronique [INN-French]; Acido etidronico [INN-Spanish]; Acidum etidronicum [INN-Latin]; (1-Hydroxyethylidene)diphosphonic acid; 1,1,1-Ethanetriol diphosphonate; 1-Hydroxyethylidene-1,1-bisphosphonate; 1-Hydroxyethane-1,1-bisphosphonic acid; 1-HYDROXY-1,1-DIPHOSPHONOETHANE; (1-Hydroxyethylidene)bis(phosphonic acid); Acidum etidronicum; (1-Hydroxyethylidene)bisphosphonic acid; (1-hydroxyethane-1,1-diyl)bis(phosphonic acid); Hydroxyethane-1,1-diphosphonic acid; (1-hydroxy-1-phosphonoethyl)phosphonic acid; 1000SL; (1-Hydroxyethylidene)diphoshonic acid; UNII-M2F465ROXU; MFCD00070585; Phosphonic acid, (1-hydroxyethylidene)di-; Ethane-1-hydroxy-1,1-bisphosphonate; CHEMBL871; M2F465ROXU; ethane-1-hydroxy-1,1-bisphosphonic acid; CHEBI:4907; 2809-21-4 (freeacid); 1-hydroxyethane 1,1-diphosphonic acid; NSC-227995; (1-hydroxyethan-1,1-diyl)bis(phosphonic acid); (1-Hydroxy-1,1-ethanediyl)bis(phosphonic acid); Phosphonic acid, P,P'-(1-hydroxyethylidene)bis-; Etidronic acid [USAN:INN:BAN]; SMR000038750; 1-Hydroxyethylidene-1,1-biphosphonate; HSDB 5898; NCGC00159352-02; EINECS 220-552-8; Phosphonic acid, 1-hydroxy-1,1-ethanediyl ester; NSC 227995; BRN 1789291; Etidronic acid (USAN/INN); C2H8O7P2; (1-hydroxy-1-phosphono-ethyl)phosphonic acid; 1-hydroxy ethylidene; Etidronate (Didronel); 1-HydroxyEthylidene-1,1-DiphosphonicAcid; Prestwick0_000863; Prestwick1_000863; Prestwick2_000863; Prestwick3_000863; DSSTox_CID_3028; EC 220-552-8; DSSTox_RID_76837; DSSTox_GSID_23028; SCHEMBL18607; BSPBio_000905; 0-02-00-00171 (Beilstein Handbook Reference); MLS002207267; MLS002695948; SPBio_002826; BPBio1_000997; GTPL7184; DTXSID6023028; M05BA01; HMS3604E03; HY-B0302; ZINC3830813; Tox21_200417; ANW-46810; BBL028139; BDBM50115102; DL-390; Etidronic acid 60% aqueous solution; NSC227995; STK721995; AKOS005524039; Etidronic acid, 60% aqueous solution; CCG-266618; DB01077; MCULE-3037955142; (1-hydroxy-ethylidene)diphosphonic acid; NCGC00159352-04; NCGC00159352-05; NCGC00257971-01; 1-hydroxyethane-1,1-diyldiphosphonic acid; CAS-2809-21-4; 1-hydroxy ethylidene-1,1-diphosphonic acid; FT-0607934; FT-0668439; (1-Hydroxy-1-phosphono-ethyl)-phosphonic acid; A11684; A23202; C07736; D02373; (1-Hydroxyethylidene)bisphosphonic acid monohydrate; J-504794; Q2758338; 1-Hydroxy Ethylidene-1,1-Diphosphonic Acid (Powder); (1-Hydroxyethane-1,1-diyl)diphosphonic acid monohydrate; 1-Hydroxyethylidenediphosphonic acid 60% aqueous solution; 1-Hydroxyethane-1,1,-diphosphonic acid 60% aqueous solution
Clinical Status
Approved
Disease Indication Paget's disease ICD-11: FB85 [1]
PubChem CID
3305
Formula
C2H8O7P2
Canonical SMILES
CC(O)(P(=O)(O)O)P(=O)(O)O
InChI
1S/C2H8O7P2/c1-2(3,10(4,5)6)11(7,8)9/h3H,1H3,(H2,4,5,6)(H2,7,8,9)
InChIKey
DBVJJBKOTRCVKF-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3305"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 206.03 Topological Polar Surface Area 135
XlogP -3.7 Complexity 211
Heavy Atom Count 11 Rotatable Bond Count 2
Hydrogen Bond Donor Count 5 Hydrogen Bond Acceptor Count 7
Full List of Drug Formulations (DFMs) Containing This API
          Etidronic acid 200 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Carilion Materials Management; Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Etidronic acid 400 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Microcrystalline cellulose; Starch, corn
                   Dosage Form Oral Tablet
                   Company Mylan Pharamceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved etidronic acid from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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