Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00291)
Name
Folic acid
Synonyms    Click to Show/Hide the Synonyms of This API
59-30-3; Folate; Pteroylglutamic acid; Vitamin M; Folacin; PteGlu; Folacid; Folvite; Vitamin B9; Vitamin Bc; Folicet; Pteroyl-L-glutamic acid; Acifolic; Cytofol; Folsan; Incafolic; Folettes; Foliamin; Folipac; Millafol; Folbal; Folsav; Pteroyl-L-monoglutamic acid; Mittafol; Pteroylmonoglutamic acid; Antianemia factor; Factor U; Folico (Italy); Folina (Italy); Foldine [France]; Acfol (Spain); Pteroylmonoglutamate; Foldine; Folcysteine; Folasic (Australia); Folcidin; Folsaure; Folaemin [Netherlands]; Vitamin Be; Nifolin [Denmark]; Folcidin (VAN); Kyselina listova [Czech]; Mission prenatal; Novofolacid [Canada]; Acide folique [INN-French]; Acido folico [INN-Spanish]; Acidum folicum [INN-Latin]; Vitamin B11; Liver Lactobacillus casei factor; PGA (VAN); Glutamic acid, pteroyl-, l-; Usaf cb-13; C19H19N7O6; N-pteroyl-L-glutamic acid; Pteroyl-L-glutamate; UNII-935E97BOY8; Kyselina listova; CHEBI:27470; AI3-26387; NSC 3073; 4-Pteridinol, 2-amino-6-((p-((1,3-dicarboxypropyl)carbamoyl)anilino)methyl)-; 59-30-3 (free acid); Glutamic acid, N-(p-(((2-amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-, l-; N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid; 935E97BOY8; CAS-59-30-3; Novofolacid; Folaemin; Nifolin; Folico; Folina; Acidum folicum; Acido folico; DSSTox_CID_2519; MFCD00079305; Dosfolat B activ; DSSTox_RID_76606; DSSTox_GSID_22519; Folic acid, 96-102%, pure; Folsaeure; Megafol; Neocepri; Acide folique; Pteroyglutamic acid; [3H]folic acid; SMR000471860; CCRIS 666; Folicet (TN); [3H]-folic acid; HSDB 2002; 32108-06-8; EINECS 200-419-0; Preconceive; Folicare; Lexpec; Pteroylglutamate; YEASTFOLATEPOLYGLUTAMATE; Folic acid [BAN:INN:JAN]; NSC-3073; Bio Science; Natur Flow; Pteroyglutamicacid; B03BB01; Folic acid [USP:INN:BAN:JAN]; NCGC00142391-03; Prestwick_230; Folic Acid,(S); Folic Acid USP/BP; Pteroyl-L-monoglutamate; Spectrum_001381; Folic acid, crystalline; Folic acid, USP grade; Folic acid, >=97%; Prestwick3_000627; Spectrum2_001459; Spectrum3_000749; Spectrum4_001751; Spectrum5_000602; bmse000299; SCHEMBL3876; CHEMBL1622; BSPBio_000594; BSPBio_002338; KBioGR_002222; KBioSS_001861; MLS001304016; MLS001335861; MLS002548873; BIDD:ER0563; BIDD:GT0641; DivK1c_000494; SPECTRUM1502020; SPBio_001357; ARONIS014410; BPBio1_000654; Folic acid, analytical standard; GTPL4562; GTPL4563; DTXSID0022519; Folic acid (JP17/USP/INN); SCHEMBL20791897; HMS501I16; KBio1_000494; KBio2_001861; KBio2_004429; KBio2_006997; KBio3_001558; Folic acid, Cell Culture Reagent; NINDS_000494; HMS1921D20; HMS2092N17; HMS2096N16; HMS2270L05; HMS3259A05; HMS3713N16; Pharmakon1600-01502020; ZINC8577218; Tox21_111559; Tox21_300127; BDBM50237629; BDBM50367343; CCG-38869; NSC758158; AKOS000503224; AKOS015895671; AKOS016007919; Tox21_111559_1; DB00158; GS-6860; NC00455; NSC-758158; SDCCGMLS-0066738.P001; IDI1_000494; SMP2_000137; Folic acid, tested according to Ph.Eur.; NCGC00016265-01; NCGC00016265-02; NCGC00016265-03; NCGC00016265-04; NCGC00016265-05; NCGC00016265-08; NCGC00142391-01; NCGC00254203-01; AC-11682; BP-13474; HY-16637; SBI-0051701.P002; Folic acid, meets USP testing specifications; A12227; C00504; D00070; Folic acid, Vetec(TM) reagent grade, >=97%; J10084; Z-4094; 079F305; Q127060; BRD-K18673820-001-07-2; Folic acid, British Pharmacopoeia (BP) Reference Standard; Folic acid, European Pharmacopoeia (EP) Reference Standard; Folic acid, United States Pharmacopeia (USP) Reference Standard; Folic acid, Pharmaceutical Secondary Standard; Certified Reference Material; N-{p-[(2-amino-4-hydroxypteridin-6-yl)methylamino]benzoyl}glutamic acid
Clinical Status
Approved
Disease Indication Vitamin deficiency ICD-11: 5B55 [1]
PubChem CID
135398658
Formula
C19H19N7O6
Canonical SMILES
C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)NC(=N3)N
InChI
1S/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s1
InChIKey
OVBPIULPVIDEAO-LBPRGKRZSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=135398658"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 441.4 Topological Polar Surface Area 209
XlogP -1.1 Complexity 767
Heavy Atom Count 32 Rotatable Bond Count 9
Hydrogen Bond Donor Count 6 Hydrogen Bond Acceptor Count 10
Full List of Drug Formulations (DFMs) Containing This API
          Folic acid 1 mg tablet Click to Show/Hide the Full List of Formulation(s):        21 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Cardinal Health
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; Exelan Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Aidarex Pharmaceuticals; RemedyRepack; West-Ward Pharmaceticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Silicon dioxide; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Blu Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 6 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Silicon dioxide; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 7 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Apace Packaging; Aphena Pharma Solutions-Tennessee; AvPAK; Cardinal Health; Central Texas Community Health Centers; Clinical Solutions Wholesale; Contract Pharmacal; Lake Eire Medical & Surgical Supply DBA Quality Care Products; Marlex Pharmaceuticals; McKesson; Mylan Pharamceuticals; NCS HealthCare of KY, Inc dba Vangard Labs; NuCare Pharmaceuticals; PD-Rx Pharmaceuticals; Par Pharmaceutical; Physicians Total Care; RemedyRepack; Safecor Health; State of Florida DOH Central Pharmacy; Sunrise Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
             Drug Formulation 8 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company Cadila Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
             Drug Formulation 9 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Lactose monohydrate; Microcrystalline cellulose; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; American Health Packaging; Cardinal Health; Major Pharmaceuticals; Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
             Drug Formulation 10 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Breckenridge Pharmaceutical
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
             Drug Formulation 11 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Clinical Solutions Wholesale; Leading Pharma; NuCare Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
             Drug Formulation 12 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Cellulose, microcrystalline; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company Clinical Solutions Wholesale; Excellium Pharmaceutical; RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
             Drug Formulation 13 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Microcrystalline cellulose; Sodium starch glycolate type a potato; Starch, corn
                   Dosage Form Oral Tablet
                   Company A-S Medication Solutions; Preferred Pharamaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
             Drug Formulation 14 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company RemedyRepack
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 15 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company State of Florida DOH Central Pharmacy
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 16 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Colloidal silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company NCS HealthCare of KY, Inc dba Vangard Labs
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 17 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Lactose monohydrate; Magnesium stearate; Colloidal silicon dioxide; Starch, corn
                   Dosage Form Oral Tablet
                   Company Qualitest Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 18 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company McKesson
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 19 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Anhydrous lactose; Magnesium stearate; Cellulose, microcrystalline; Starch, potato
                   Dosage Form Oral Tablet
                   Company Jubilant Cadista Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 20 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a potato
                   Dosage Form Oral Tablet
                   Company AiPing Pharmaceutical; Method Pharmaceuticals; NuCare Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 21 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Lactose monohydrate; Magnesium stearate; Cellulose, microcrystalline; Sodium starch glycolate type a corn
                   Dosage Form Oral Tablet
                   Company Method Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 FDA label for approved folic acid from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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