General Information of API (ID: D00350)
Name
Lanthanum carbonate
Synonyms    Click to Show/Hide the Synonyms of This API
Lanthanum Carbonate; 587-26-8; Lanthanum sesquicarbonate; Carbonic acid, lanthanum(3+) salt (3:2); UNII-0M78EU4V9H; lanthanum(3+);tricarbonate; 0M78EU4V9H; Dilanthanum tricarbonate; Carbonic acid,lanthanum(3+) salt (3:2), octahydrate (8CI,9CI); Lanthanum(3 ) carbonate; EINECS 209-599-5; HSDB 7758; lanthanum(iii) carbonate; Lanthanum(3+) carbonate; Lanthanum Carbonate powder; ACMC-1BB7U; C3La2O9; Lanthanum (III) carbonate; EC 209-599-5; lanthanum carbonate (2:3); Lanthanum carbonate anhydrous; DTXSID30890512; DB06792; Q421317; Carbonic acid,lanthanum(3+) salt (3:2), hydrate (9CI)
Clinical Status
Approved
Disease Indication Hyperphosphatemia ICD-11: 5C64 [1]
PubChem CID
168924
Formula
C3La2O9
Canonical SMILES
C(=O)([O-])[O-].C(=O)([O-])[O-].C(=O)([O-])[O-].[La+3].[La+3]
InChI
1S/3CH2O3.2La/c3*2-1(3)4;;/h3*(H2,2,3,4);;/q;;;2*+3/p-6
InChIKey
NZPIUJUFIFZSPW-UHFFFAOYSA-H
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=168924"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 457.84 Topological Polar Surface Area 190
XlogP N.A. Complexity 18.8
Heavy Atom Count 14 Rotatable Bond Count 0
Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 9
Full List of Drug Formulations (DFMs) Containing This API
          Lanthanum carbonate 1000 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Talc; Silicon dioxide; Dextrates; Hydroxypropyl cellulose
                   Dosage Form Chewable Tablet
                   Company Lupin Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Silicon dioxide; Dextrates
                   Dosage Form Chewable Tablet
                   Company Prasco; Shire
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Lanthanum carbonate 500 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Talc; Silicon dioxide; Dextrates; Hydroxypropyl cellulose
                   Dosage Form Chewable Tablet
                   Company Lupin Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Silicon dioxide; Dextrates
                   Dosage Form Chewable Tablet
                   Company Avera McKennan Hospital; Cardinal Health; Prasco; Shire
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
          Lanthanum carbonate 750 mg tablet Click to Show/Hide the Full List of Formulation(s):          2 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Talc; Silicon dioxide; Dextrates; Hydroxypropyl cellulose
                   Dosage Form Chewable Tablet
                   Company Lupin Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Silicon dioxide; Dextrates
                   Dosage Form Chewable Tablet
                   Company Prasco; Shire
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [2]
References
1 FDA label for approved lanthanum carbonate from the official website of the U.S. Food and Drug Administration.
2 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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