Details of the Active Pharmaceutical Ingredient (API)
General Information of API (ID: D00359) | |||||
---|---|---|---|---|---|
Name |
Levocarnitine
|
||||
Synonyms |
Click to Show/Hide the Synonyms of This API
L-carnitine; Levocarnitine; vitamin BT; (R)-Carnitine; Carnitor; 541-15-1; (-)-Carnitine; (-)-L-Carnitine; Karnitin; L-(-)-Carnitine; Carnitene; bicarnesine; Levocarnitina; Metina; L-Carnitine inner salt; Levocarnitinum; Carniking; Carnilean; Carnitine, (-)-; L(-)-Carnitine; Levocarnitinum [Latin]; Levocarnitina [Spanish]; Carniking 50; (3R)-3-hydroxy-4-(trimethylammonio)butanoate; gamma-Trimethyl-beta-hydroxybutyrobetaine; gamma-Trimethyl-ammonium-beta-hydroxybutirate; 1-CARNITINE; (3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate; 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner salt; DRG-0211; UNII-0G389FZZ9M; (R)-(3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide; R-(-)-3-hydroxy-4-trimethylaminobutyrate; 3-carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium; L-gamma-trimethyl-beta-hydroxybutyrobetaine; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (R)-; (3-Carboxy-2-hydroxypropyl)trimethyl-ammonium hydroxide, inner salt; (L-3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide, inner salt; CHEMBL1149; Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L-; Carnicor; 0G389FZZ9M; (R)-3-Hydroxy-4-(trimethylammonio)butyrate; Carnitolo; Carnovis; Carrier; CHEBI:16347; Lefcar; (-)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate; L-carnitine Base; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, hydroxide, inner salt; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)-; 44985-71-9; (R)-3-hydroxy-4-(trimethylammonio)butanoate; L(-)-Carnitine, 99+%; Levocarnitine [USAN:INN]; L Carnitine; MFCD00038747; vitamin B T; Carnitor (TN); SMR000112475; carnitine (L-form); gamma-Trimethyl-hydroxybutyrobetaine; (3R)-3-hydroxy-4-(trimethylamino)butanoic acid; 3-hydroxy-4-trimethylammoniobutanoate; EINECS 208-768-0; Carnipass; delta-carnitine; Levocarnitine (JAN/USP/INN); L-Carnitin; Malonyl-Carnitin; HSDB 7588; Carnipass 20; Carnitine, L-; L-Carnitine,(S); Car-OH; Levocarnitine [USAN:USP:INN:BAN]; PubChem5901; (R)-3-Hydroxy-4-trimethylammoniobutyrate; bmse000211; L-carnitine (Levocarnitine); SCHEMBL21970; MLS001332549; MLS001332550; ARONIS24315; BIDD:GT0603; 1-Propanaminium,3-carboxy-2-hydroxy-N,N,N-trimethyl-; GTPL4780; DTXSID4023208; HMS2093J13; HMS2267H24; Pharmakon1600-01505437; HY-B0399; (R)-(3-Carboxy-2-hydroxypropyl)trimethylammonium hydroxide, inner salt; ABP000696; Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide,inner salt; ANW-31960; BDBM50037268; CC0198; NSC741806; NSC759132; SBB058880; AKOS005267245; BCP9000830; CCG-213241; DB00583; KS-1422; NSC-741806; NSC-759132; 6-CHLORO-3-HYDROXY(1H)INDAZOLE; 3-hydroxy-4-trimethylammoniobutanoic acid; AS-11974; gamma-L-trimethyl-beta-hydroxybutyrobetaine; L-Carnitin 100 microg/mL in Acetonitrile; L-Carnitine inner salt, synthetic, >=98%; ST50824805; C00318; D02176; (3R)-3-oxidanyl-4-(trimethylazaniumyl)butanoate; (R)-3-Hydroxy-4-(trimethylammonio)butanoic acid; AB00919083_05; AB00919083_06; (R)-(-)-3-Hydroxy-4-(trimethylammonio)butyrate; A829968; (3R)-(-)-3-Hydroxy-4-(trimethylammonio)butanoate; Q20735709; (3R)-(-)-3-Hydroxy-4-(trimethylammonio)butanoate 99+%; L-carnitine(Levocarnitine)/Carnitor, vitamin BT, Karnitin; UNII-S7UI8SM58A component PHIQHXFUZVPYII-ZCFIWIBFSA-N; Levocarnitine, European Pharmacopoeia (EP) Reference Standard; Levocarnitine, United States Pharmacopeia (USP) Reference Standard; 3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium hydroxide, inner; 1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)- (9CI); Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, hydroxide, inner salt, L- (8CI); Levocarnitine, Pharmaceutical Secondary Standard; Certified Reference Material
|
||||
Clinical Status |
Approved
|
||||
Disease Indication | Cognitive impairment | ICD-11: 6D71 | [1] | ||
PubChem CID | |||||
Formula |
C7H15NO3
|
||||
Canonical SMILES |
C[N+](C)(C)C[C@@H](CC(=O)[O-])O
|
||||
InChI |
1S/C7H15NO3/c1-8(2,3)5-6(9)4-7(10)11/h6,9H,4-5H2,1-3H3/t6-/m1/s1
|
||||
InChIKey |
PHIQHXFUZVPYII-ZCFIWIBFSA-N
|
||||
Click to Show/Hide the Molecular Data (Structure/Property) of This API | |||||
Structure |
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=10917"></iframe>
|
||||
3D MOL | 2D MOL | ||||
Physicochemical Properties | Molecular Weight | 161.2 | Topological Polar Surface Area | 60.4 | |
XlogP | -0.2 | Complexity | 134 | ||
Heavy Atom Count | 11 | Rotatable Bond Count | 3 | ||
Hydrogen Bond Donor Count | 1 | Hydrogen Bond Acceptor Count | 3 | ||
Full List of Drug Formulations (DFMs) Containing This API | ||||||
---|---|---|---|---|---|---|
Levocarnitine 330 mg tablet | Click to Show/Hide the Full List of Formulation(s): 3 Formulation(s) | |||||
Drug Formulation 1 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Povidone; Cellulose, microcrystalline
|
|||||
Dosage Form | Oral Tablet | |||||
Company | Avera McKennan Hospital; Hi-Tech Pharmacal | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Povidone | DIG Info | Cholesterol 25-hydroxylase (IC50 = 78.3 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Drug Formulation 2 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Povidone; Cellulose, microcrystalline; Sodium starch glycolate type a potato
|
|||||
Dosage Form | Oral Tablet | |||||
Company | Rising Pharmaceuticals | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Povidone | DIG Info | Cholesterol 25-hydroxylase (IC50 = 78.3 uM) | [2] | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
Drug Formulation 3 | DFM Info click to show the detail info of this DFM | |||||
All DIGs | Click to Show/Hide the Full List of DIGs in This DFM
Magnesium stearate; Microcrystalline cellulose; Povidone, unspecified
|
|||||
Dosage Form | Oral Tablet | |||||
Company | Leadiant Biosciences | |||||
DIG(s) with Biological Activity | ||||||
DIG Name | DIG Info | Representative Biological Activity of This DIG | REF | |||
Magnesium stearate | DIG Info | Albendazole monooxygenase (Protein expression downregulation) | [3] | |||
If you find any error in data or bug in web service, please kindly report it to Dr. Zhang and Dr. Mou.