Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00572)
Name
Pyridoxine
Synonyms    Click to Show/Hide the Synonyms of This API
pyridoxine; 65-23-6; vitamin B6; Pyridoxol; Gravidox; Pyridoxin; 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine; Hydoxin; Adermine; Pyridoxolum; 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-; 5-Hydroxy-6-methyl-3,4-pyridinedimethanol; 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol; Pyridoxinum; Piridossina [DCIT]; 3-Hydroxy-4,5-dimethylol-alpha-picoline; Pyridoxinum [INN-Latin]; Piridossina; Piridoxina [INN-Spanish]; Piridoxina; Pyridoxine [INN:BAN]; Aderoxine; 2-Picoline-4,5-dimethanol, 3-hydroxy-; 2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine; Hexa-Betalin; 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine; 2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine; CHEBI:16709; UNII-KV2JZ1BI6Z; (5-Hydroxy-6-methylpyridine-3,4-diyl)dimethanol; EINECS 200-603-0; Pyridoxin hydrochloride; 4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol; 4,5-bis(hydroxymethyl)-2-methyl-pyridin-3-ol; Pyridoxine free base; 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin [German]; Prestwick0_000623; Prestwick1_000623; Prestwick2_000623; Prestwick3_000623; 2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine; Adermin hydrochloride; KV2JZ1BI6Z; 12001-77-3; TimTec1_000657; Oprea1_061614; BSPBio_000586; CBDivE_015627; SPBio_002805; BPBio1_000646; Pyridoxinum hydrochloricum; 2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin; Pyridoxine hydrogen chloride; M.V.I.-12; STK177324; 65-23-6 (FREE BASE); DB00165; CAS-58-56-0; SMP2_000230; NCGC00016261-01; NCGC00016261-03; DSSTox_CID_3541; C00314; DSSTox_RID_77070; DSSTox_GSID_23541; AC-907/25014218; 2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine; Adermin; Bezatin; Pirivitol; Infuvite Pediatric; CAS-65-23-6; NSC36225; Pyridoxine (Vit B6); SR-05000001644; NCGC00164317-01; M.V.I.-12 Lyophilized; Pridoxine; VitaminB6; Pyridoxine (INN); Beesix (Salt/Mix); nchembio.93-comp1; Becilan (Salt/Mix); Benadon (Salt/Mix); Hexobion (Salt/Mix); Vitamin B6 (TN); Pyridoxol, Vitamin B6; Pyridoxol; Vitamin B6; Pyridoxine, >=98%; Hexabetalin (Salt/Mix); Vitamin b6,hydrochloride; LS-134393; bmse000288; SCHEMBL3506; CHEMBL1364; BIDD:PXR0180; P5669_SIGMA; DTXSID4023541; ZINC49154; NSC36225 (HCL); Pyridoxol, Vitamin B6, Gravidox; AIDS006784; HMS2093L07; KUC106691N; Pharmakon1600-01505453; AIDS-006784; ALBB-022452; BCP27975; HY-B1328; Tox21_113644; Tox21_300365; ANW-46602; BBL005552; BDBM50103505; MFCD00006335; NSC759148; SBB065653; ZINC00049154; 3-hydroxy-2-Picoline-4,5-dimethanol; AKOS005410791; Tox21_113644_1; CCG-213453; CS-W019950; MCULE-7725975962; NSC-759148; NCGC00016261-02; NCGC00016261-04; NCGC00016261-05; NCGC00016261-08; NCGC00164317-02; NCGC00254340-01; AC-14512; AK-27118; DS-11013; KSC-11-207-23; SBI-0206844.P001; 3-Hydroxy-4,5-dimethylol-.alpha.-picoline; DB-073595; AM20070169; FT-0631288; FT-0674200; ST50907853; EN300-39851; 4,5-bis(hydroxymethyl)-2-methylpyridine-3-ol; D08454; M-7962; 4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol #; A835033; Q423746; Q-201646; SR-05000001644-1; SR-05000001644-3; 2-Methyl-3-oxylato-4,5-bis(hydroxymethyl)pyridinium; 2B3E07D2-E4CC-4CC5-B085-6070BA01F9F0; Z955123748; 2-methyl-3-hydroxy-4-hydroxymethyl-5-hydroxymethyl pyridine
Clinical Status
Approved
Disease Indication Vitamin deficiency ICD-11: 5B55 [1]
PubChem CID
1054
Formula
C8H11NO3
Canonical SMILES
CC1=NC=C(C(=C1O)CO)CO
InChI
1S/C8H11NO3/c1-5-8(12)7(4-11)6(3-10)2-9-5/h2,10-12H,3-4H2,1H3
InChIKey
LXNHXLLTXMVWPM-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=1054"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 169.18 Topological Polar Surface Area 73.6
XlogP -0.8 Complexity 142
Heavy Atom Count 12 Rotatable Bond Count 2
Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 4
Full List of Drug Formulations (DFMs) Containing This API
          Pyridoxine 25 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company VersaPharm
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
          Pyridoxine 50 mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Magnesium stearate; Silicon dioxide; Calcium phosphate, dibasic, anhydrous; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company VersaPharm
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
References
1 Vitamin B6 (Pyridoxine).
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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