Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00629)
Name
Sodium bicarbonate
Synonyms    Click to Show/Hide the Synonyms of This API
SODIUM BICARBONATE; 144-55-8; Sodium hydrogen carbonate; Sodium hydrogencarbonate; Baking soda; Carbonic acid monosodium salt; Sodium acid carbonate; Bicarbonate of soda; Sodium hydrocarbonate; Meylon; Acidosan; Natriumhydrogenkarbonat; NaHCO3; Monosodium carbonate; Jusonin; Soludal; Soda Mint; Soda (van); Carbonic acid sodium salt (1:1); Sodium bicarbonate (1:1); Monosodium hydrogen carbonate; MFCD00003528; Carbonic acid, monosodium salt; UNII-8MDF5V39QO; 8MDF5V39QO; CHEBI:32139; Natron; Col-evac; Sel De vichy; Natrium bicarbonicum; Soda Ash; Natrii hydrogencarbonas; Natrium hydrogencarbonicum; sodium hydrogen-carbonate; Caswell No. 747; Sodium carbonate (Na(HCO3)); Sodium bicarbonate, 99+%, for HPLC; Sodium bicarbonate, 99+%, extra pure; Sodium bicarbonate, 99.5%, for analysis; Sodium bicarbonate in plastic container; Meylon (TN); Sodium bicarbonate, 99.7+%, ACS reagent; CCRIS 3064; HSDB 697; Sodium bicarbonate, 99.5%, for biochemistry; Neut (TN); NSC-134031; sodium;hydrogen carbonate; EINECS 205-633-8; Sodium bicarbonate solution; EPA Pesticide Chemical Code 073505; NSC 134031; Sodium bicarbonate [USP:JAN]; sodium bicabonate; sodium bicarbonat; bicarbonate sodium; sodiumbi-carbonate; sodium bi-carbonate; sodium bicarbonate-; Sodium bi carbonate; natriumhydrogencarbonat; CHNaO3; sodium hydrogencabonate; sodium hydrogencarbonat; sodiumhydrogen carbonate; PubChem23592; sodium hydrogen cabonate; ACMC-20ajp0; hydrogen carbonate sodium; Sodium bicarbonate, USP; sodium hyd-rogencarbonate; sodium-hydrogen-carbonate; SODIUM BICARBONIATE; EC 205-633-8; CHEMBL1353; INS NO.500(II); DTXSID9021269; INS-500(II); Sodium bicarbonate (JP17/USP); sodium hydrogen carbonate solution; E-500(II); Sodium bicarbonate -40-+140 mesh; Sodium bicarbonate, Biochemical Grade; AKOS015836321; AKOS015951222; Sodium hydrogen carbonate, Puratronic?; DB01390; Sodium bicarbonate A.C.S. reagent grade; Bicarbonate, 1M buffer solution, pH 8.0; Bicarbonate, 1M buffer solution, pH 8.5; FT-0645108; C12603; D01203; 3-Phenyl-2-thioxotetrahydropyrimidin-4(1H)-one; Sodium bicarbonate, 1M buffer solution, pH 8.0; Sodium bicarbonate, 1M buffer solution, pH 9.0; Q179731; Sodium bicarbonate, 1M buffer solution, pH 10.0; Sodium bicarbonate, HPLC, Meets ACS Specifications; Sodium bicarbonate 5% w/v solution in water (+/- 0.3%); Saturated aqueous Sodium bicarbonate solution (~9.6% wt/wt/)
Clinical Status
Approved
Disease Indication Metabolic acidosis ICD-11: 5C73 [1]
PubChem CID
516892
Formula
CHNaO3
Canonical SMILES
C(=O)(O)[O-].[Na+]
InChI
1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1
InChIKey
UIIMBOGNXHQVGW-UHFFFAOYSA-M
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=516892"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 84.007 Topological Polar Surface Area 60.4
XlogP N.A. Complexity 33.9
Heavy Atom Count 5 Rotatable Bond Count 0
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 3
Full List of Drug Formulations (DFMs) Containing This API
          Sodium bicarbonate 325 mg tablet Click to Show/Hide the Full List of Formulation(s):          3 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Talc; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Richmond Pharmaceuticals; Rugby Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Rugby Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Reliable 1 Laboratires
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
          Sodium bicarbonate 650 mg tablet Click to Show/Hide the Full List of Formulation(s):          5 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Talc; Croscarmellose sodium; Silicon dioxide; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Rugby Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 2 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Talc; Croscarmellose sodium; Silicon dioxide; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Rising Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
Silicon dioxide DIG Info Albendazole monooxygenase (Protein expression downregulation) [3]
             Drug Formulation 3 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Rugby Laboratories
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
             Drug Formulation 4 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Croscarmellose sodium; Cellulose, microcrystalline
                   Dosage Form Oral Tablet
                   Company Cardinal Health; Gericare Pharmaceuticals; Reliable 1 Laboratires
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
             Drug Formulation 5 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Stearic acid; Croscarmellose sodium; Microcrystalline cellulose
                   Dosage Form Oral Tablet
                   Company Aphena Pharma Solutions-Tennessee; Richmond Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Stearic acid DIG Info Phosphodiesterase 3A (IC50 = 3.1 uM) [2]
Carmellose sodium DIG Info Albendazole monooxygenase (Protein expression upregulation) [3]
References
1 FDA label for approved sodium bicarbonate from the official website of the U.S. Food and Drug Administration.
2 The activities of drug inactive ingredients on biological targets. Science. 2020 Jul 24;369(6502):403-413.
3 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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