Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00935)
Name	Cephapirin
Synonyms	Click to Show/Hide the Synonyms of This API cephapirin; Cefapirin; Cephapirine; Cefaprin; 21593-23-7; Cefapirina; Cefapirine; Cefapirinum; Cefadyl; CEPR; Cefapirine [INN-French]; Cefapirinum [INN-Latin]; Cefapirina [INN-Spanish]; Cefatrexyl; Ambrocef; Cefatrex; CHEBI:554446; 7-(2-(4-Pyridylthio)acetamido)cephalosporanic acid; UNII-89B59H32VN; 89B59H32VN; Cefaprin sodium; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-8-oxo-7-(((4-pyridinylthio)acetyl)amino)-, (6R-trans)-; Cefa; Cefapirin [INN:BAN]; ANTIBIOTIC BL-P1322; Cefapirin (BAN); Metricure (TN); (6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(pyridin-4-ylthio)acetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-(acetoxymethyl)-8-oxo-7-{[(pyridin-4-ylsulfanyl)acetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 24356-60-3; Cefapilin; 356C603; Cefa-Lak; HSDB 3215; Cefa -ak; EINECS 244-466-5; BRN 1095157; NSC179171; Spectrum_000112; Prestwick0_000851; Prestwick1_000851; Prestwick2_000851; Spectrum2_000103; Spectrum3_000333; Spectrum4_000270; Spectrum5_000671; Epitope ID:116226; SCHEMBL3205; CHEMBL1599; Lopac0_000279; BSPBio_001965; KBioGR_000740; KBioSS_000552; (6R,7R)-3-(Acetoxymethyl)-8-oxo-7-(2-(4-pyridylthio)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carbonsaeure; 3-(Hydroxymethyl)-8-oxo-7-(2-(4-pyridylthio)acetamidol-5-thia-1-azabicyclo(4.2.0)oct-2-en-2carbonsaeure acetat; 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(hydroxymethyl)-8-oxo-7-(2-(4-pyridylthio)acetamido)-, acetate (ester); DivK1c_000042; SPBio_000086; SPBio_002782; Cephalosporanic acid, 7-(2-(4-pyridylthio)acetamido)-; DTXSID9022784; KBio1_000042; KBio2_000552; KBio2_003120; KBio2_005688; KBio3_001185; NINDS_000042; ZINC3830511; BDBM50370592; AKOS015896499; DB01139; IDI1_000042; (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-{[(pyridin-4-ylthio)acetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-acetoxymethyl-7-[(pyridin-4-ylsulfanyl)acetamido]-3,4-didehydrocepham-4-carboxylic acid; SBI-0050267.P004; C06896; D07636; Q549803; J-014163; (6R,7R)-3-(acetoxymethyl)-8-oxo-7-[[2-(4-pyridylsulfanyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(pyridin-4-ylsulfanyl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, (6R,7R)-
Clinical Status	Approved
PubChem CID	30699
Formula	C17H17N3O6S2
Canonical SMILES	CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)CSC3=CC=NC=C3)SC1)C(=O)O
InChI	1S/C17H17N3O6S2/c1-9(21)26-6-10-7-28-16-13(15(23)20(16)14(10)17(24)25)19-12(22)8-27-11-2-4-18-5-3-11/h2-5,13,16H,6-8H2,1H3,(H,19,22)(H,24,25)/t13-,16-/m1/s1
InChIKey	UQLLWWBDSUHNEB-CZUORRHYSA-N
	Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure	<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=30699"></iframe>
Structure	3D MOL		2D MOL
Physicochemical Properties	Molecular Weight	423.5	Topological Polar Surface Area	177
	XlogP	-1.1	Complexity	707
	Heavy Atom Count	28	Rotatable Bond Count	8
	Hydrogen Bond Donor Count	2	Hydrogen Bond Acceptor Count	9

Full List of Drug Formulations (DFMs) Containing This API
Cephapirin 200mg/10ml injectable			Click to Show/Hide the Full List of Formulation(s): 1 Formulation(s)
Drug Formulation 1	DFM Info click to show the detail info of this DFM
All DIGs	Click to Show/Hide the Full List of DIGs in This DFM Peanut Oil Gel
Dosage Form	Injectable
Company	Boehringer Ingelheim Vetmedica
DIG(s) with Biological Activity
	DIG Name	DIG Info	Representative Biological Activity of This DIG	REF
	Glyceryl monooleate	DIG Info	Diacylglycerol kinase alpha (Ki = 91000 nM)	[1]

References
1	Identification of a novel DGKalpha inhibitor for XLP-1 therapy by virtual screening. Eur J Med Chem. 2019; 164:378-390.

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