Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00953)
Name
Clevidipine
Synonyms    Click to Show/Hide the Synonyms of This API
Clevidipine; Clevidipine butyrate; 167221-71-8; Cleviprex; Clevelox; Methyl (1-oxobutoxy)methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dime thyl-3,5-pyridinedicarboxylate; 3-((butyryloxy)methyl) 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; Methyl (1-oxobutoxy)methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate; rac-Clevidipine; 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-methyl 5-[(1-oxobutoxy)methyl] ester; 5-O-(butanoyloxymethyl) 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; METHYL 5-{[(BUTANOYLOXY)METHOXY]CARBONYL}-4-(2,3-DICHLOROPHENYL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3-CARBOXYLATE; (-)-R-Clevidipine; 166432-28-6; SR-01000945183; Clevidipine [USAN:INN]; Cleviprex (TN); 3-[(Butyryloxy)methyl] 5-Methyl 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; H 324/38; Clevidipine, Cleviprex; Cleviprex (Clevidipine); Clevidipine (USAN/INN); DSSTox_CID_31450; DSSTox_RID_97336; DSSTox_GSID_57661; C21H23Cl2NO6; cc-161; SCHEMBL115522; GTPL7468; Clevidipine Butyrate;Clevidipine; CHEMBL1237132; DTXSID6057661; CHEBI:135738; HMS3604H21; HMS3651G10; HMS3884L03; AMY22141; BCP22676; BCP22687; EX-A2898; Tox21_113923; ABP001090; BDBM50088387; CC0258; MFCD00940070; s2080; AKOS015896325; CCG-269294; CS-1427; DB04920; MCULE-6863602192; NCGC00262928-01; 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl (1-oxobutoxy)methyl ester; AC-24370; AK163183; AS-19935; butyroxymethyl methyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; HY-17436; DB-064636; C3503; CAS-167221-71-8; FT-0659562; FT-0688416; SW220087-1; Z1845; A11746; D08892; W-5232; AB01566888_01; 221C718; H324/38; H-324/38; J-520103; Q5132338; SR-01000945183-1; SR-01000945183-2; Z1691545244; (Butanoyloxy)methyl methyl (4RS)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 3-[(Butyryloxy)methyl] 5-Methyl 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate / 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic Aicd 3-[(Butyryloxy)methyl] 5-Methyl Ester; 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic Aicd 3-[(Butyryloxy)methyl] 5-Methyl Ester; Butyroxymethyl methyl 4-(2',3'-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylat; O3-(butanoyloxymethyl) O5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Clinical Status
Approved
PubChem CID
153994
Formula
C21H23Cl2NO6
Canonical SMILES
CCCC(=O)OCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C
InChI
1S/C21H23Cl2NO6/c1-5-7-15(25)29-10-30-21(27)17-12(3)24-11(2)16(20(26)28-4)18(17)13-8-6-9-14(22)19(13)23/h6,8-9,18,24H,5,7,10H2,1-4H3
InChIKey
KPBZROQVTHLCDU-UHFFFAOYSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=153994"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 456.3 Topological Polar Surface Area 90.9
XlogP 4.3 Complexity 748
Heavy Atom Count 30 Rotatable Bond Count 10
Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 7
Full List of Drug Formulations (DFMs) Containing This API
          Clevidipine 25mg/50ml Emulsion Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Soybean Oil; Glycerin; Purified Egg Yolk Phospholipids; Oleic Acid; Disodium Edetate
                   Dosage Form Emulsion
                   Company Chiesi
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Oleic acid DIG Info Liver lipid-binding protein (Ki = 180 nM) [1]
          Clevidipine 50mg/100ml Emulsion Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Soybean Oil; Glycerin; Purified Egg Yolk Phospholipids; Oleic Acid; Disodium Edetate
                   Dosage Form Emulsion
                   Company Chiesi
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Oleic acid DIG Info Liver lipid-binding protein (Ki = 180 nM) [1]
          Clevidipine 125mg/250ml Emulsion Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Soybean Oil; Glycerin; Purified Egg Yolk Phospholipids; Oleic Acid; Disodium Edetate
                   Dosage Form Emulsion
                   Company Chiesi
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Oleic acid DIG Info Liver lipid-binding protein (Ki = 180 nM) [1]
References
1 Characterization of the drug binding specificity of rat liver fatty acid binding protein. J Med Chem. 2008 Jul 10; 51(13):3755-64.

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