Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D00957)
Name
Clomiphene citrate
Synonyms    Click to Show/Hide the Synonyms of This API
Clomifene citrate; CLOMIPHENE CITRATE; 50-41-9; Zuclomiphene citrate; Clomid; Clomiphene citrate salt; Clomiphene A citrate; cis-Clomiphene citrate; Milophene; Serophene; Chloramiphene; Omifin; Clomifene citrate (Serophene); UNII-UY5X264QZV; Clostilbegyt; RMI 16289; Clomivid; Clomphid; Dyneric; Genozym; Ikaclomin; 2-(4-(2-Chloro-1,2-diphenylvinyl)phenoxy)-N,N-diethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate; Zuclomiphene (citrate); MFCD00058322; NSC 35770; 7619-53-6; UY5X264QZV; 50-41-9 (CITRATE); MRL 41; Zuclomid; RMI 16312; (Z)-2-(4-(2-chloro-1,2-diphenylvinyl)phenoxy)-N,N-diethylethan-1-amine 2-hydroxypropane-1,2,3-tricarboxylate; (Z)-Clomiphene citrate; Ethanamine, 2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethyl-,2-hydroxy-1,2,3-propanetricarboxylate (1:1); MER-41; MRL-41; NSC 151466; NSC-35770; Triethylamine, 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)-, citrate (1:1); CAS-50-41-9; Clomiphene citrate, cis-; Triethylamine, 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)-, citrate (1:1), (Z)-; MLS001332629; MLS002207099; ARONIS23854; SCHEMBL223472; SPECTRUM1500196; Clomiphene citrate salt, 97%; SGCUT00109; CHEMBL1213137; HMS501H04; HY-B1617A; HMS1920O19; HMS2091G06; HMS2232D12; Pharmakon1600-01500196; AMY33425; BCP03057; to_000032; CCG-39553; NSC151466; NSC756698; s2561; SBB080555; AKOS005111131; BCP9000541; DS-6814; NSC-151466; NSC-756698; SB17214; NCGC00017008-01; NCGC00017008-02; NCGC00017008-03; NCGC00094626-01; NCGC00094626-02; NCGC00164385-01; AC-19685; AC-32011; Ethanamine, 2-(4-((1Z)-2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1); BCP0726000214; AB0006636; 2-[4-(2-Chloro-1,2-diphenylvinyl)phenoxy; CS-0111663; SW196898-3; C08161; Triethylamine,2-diphenylvinyl)phenoxy]-, citrate; SR-05000001591; SR-05000001591-1; Q27291328; Triethylamine,2-diphenylvinyl)phenoxy]-, citrate (1:1); UNII-1B8447E7YI component PYTMYKVIJXPNBD-OQKDUQJOSA-N; Triethylamine,2-diphenylvinyl)phenoxy]-, citrate (1:1), (Z)-; (2)2-[p-(2-Chloro-1,2-diphenylvinyl)phenoxy]triethylamine citrate (1:1); 2-(4-[2-Chloro-1,2-Diphenylethenyl]Phenoxy)-N,N-Diethylethanamine Citrate salt; (2-(4-[(Z)-2-CHLORO-1,2-DIPHENYLETHENYL]PHENOXY)ETHYL)DIETHYLAMINE, 2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID; {2-[4-((1Z)-2-chloro-1,2-diphenylvinyl)phenoxy]ethyl}diethylamine, 2-hydroxypr opane-1,2,3-tricarboxylic acid; {2-[4-(2-Chloro-1,2-diphenylvinyl)phenoxy]ethyl}diethylamine 2-hydroxypropane-1,2,3-tricarboxylic acid salt; 2-({4-[(Z)-2-chloro-1,2-diphenylethenyl]phenyl}oxy)-N,N-diethylethanamine 2-hydroxypropane-1,2,3-tricarboxylate (salt); Ethanamine, 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethyl-, (Z)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (9CI); Ethanamine,2-diphenylethenyl)phenoxy]-N,N-diethyl-, (Z)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1); Ethanamine,2-diphenylethenyl)phenoxy]-N,N-diethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)
Clinical Status
Approved
PubChem CID
3033832
Formula
C32H36ClNO8
Canonical SMILES
CCN(CC)CCOC1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\\Cl)/C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O)O)O
InChI
1S/C26H28ClNO.C6H8O7/c1-3-28(4-2)19-20-29-24-17-15-22(16-18-24)25(21-11-7-5-8-12-21)26(27)23-13-9-6-10-14-23;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,3-4,19-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
InChIKey
PYTMYKVIJXPNBD-OQKDUQJOSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3033832"></iframe>
3D MOL is unavailable 2D MOL
Physicochemical Properties Molecular Weight 598.1 Topological Polar Surface Area 145
XlogP N.A. Complexity 708
Heavy Atom Count 42 Rotatable Bond Count 14
Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 9
Full List of Drug Formulations (DFMs) Containing This API
          Clomiphene Citrate 50mg tablet Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Starch, Corn; Lactose Monohydrate; Magnesium Stearate; Sucrose
                   Dosage Form Tablet
                   Company Bryant Ranch Prepack; Nucare Pharmaceuticals
                   DIG(s) with
                   Biological Activity
DIG Name DIG Info Representative Biological Activity of This DIG REF
Magnesium stearate DIG Info Albendazole monooxygenase (Protein expression downregulation) [1]
References
1 Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells. Pharm Res. 2010 Aug;27(8):1703-12.

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