Details of the Active Pharmaceutical Ingredient (API)

General Information of API (ID: D01088)
Name
Flunisolide
Synonyms    Click to Show/Hide the Synonyms of This API
flunisolide; 3385-03-3; Aerobid; Synaclyn; Nasarel; Syntaris; Flunisolide HFA; Nasalide; Bronalide; Rhinalar; Aerospan; Flunisolide anhydrous; Flunisolida; Flunisolidum; Aerospan HFA; Lunis; RS-3999; CHEBI:5106; UNII-78M02AA8KF; Nisolid; Soluzione; MLS002153928; 78M02AA8KF; Aerobid M; DSSTox_CID_25534; DSSTox_RID_80936; DSSTox_GSID_45534; Pregna-1,4-diene-3,20-dione,6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-,(6a,11b,16a)-; (1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one; CAS-3385-03-3; Flunisolide [INN]; Flunisolide [anhydrous]; Flunisolidum [INN-Latin]; Flunisolida [INN-Spanish]; Flunie; Syntaris Hayfever; NCGC00016983-01; lunisolide anhydrous; Prestwick_223; EINECS 222-193-2; RS 3999; Flunisolide(Nasalide)/; Prestwick0_000643; Prestwick1_000643; Prestwick2_000643; Prestwick3_000643; SCHEMBL4351; CHEMBL1512; BSPBio_000645; SPBio_002566; BPBio1_000711; GTPL7076; DTXSID1045534; HMS1570A07; HMS2097A07; HMS2236A06; HMS3259L10; HMS3714A07; HY-B1121; ZINC4097305; Tox21_110725; ABP000528; BDBM50248007; MFCD00133324; AKOS025402038; Tox21_110725_1; AC-3514; BCP9000696; CCG-220643; CS-4713; DB00180; NC00716; 6-Fluoro-11,21-dihydroxy-16,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione; NCGC00179492-01; NCGC00179492-03; 6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16, 17-acetal with acetone; Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone; Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-; Q834; SMR001233272; F0437; (6a,11b,16a)-6-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione; C07005; 32277-EP2281815A1; 32277-EP2295402A2; 32277-EP2301933A1; 32277-EP2305640A2; 32277-EP2308562A2; 32277-EP2311827A1; 32277-EP2371811A2; 385F033; Q3746835; BRD-K49577446-001-03-1; 6-Fluoro-11,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide; (1S,2S,4R,8S,9S,11S,12S,13R,19S)-19-fluoro-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-dien-16-one; 6alpha-fluoro-11beta,21-dihydroxy-16alpha,17alpha-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
Clinical Status
Approved
PubChem CID
82153
Formula
C24H31FO6
Canonical SMILES
C[C@]12C[C@@H]([C@H]3[C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)CO)C[C@@H](C5=CC(=O)C=C[C@]35C)F)O
InChI
1S/C24H31FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1
InChIKey
XSFJVAJPIHIPKU-XWCQMRHXSA-N
   Click to Show/Hide the Molecular Data (Structure/Property) of This API
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=82153"></iframe>
3D MOL 2D MOL
Physicochemical Properties Molecular Weight 434.5 Topological Polar Surface Area 93.1
XlogP 2.5 Complexity 910
Heavy Atom Count 31 Rotatable Bond Count 2
Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 7
Full List of Drug Formulations (DFMs) Containing This API
          Flunisolide 0.078mg/inh aerosol Click to Show/Hide the Full List of Formulation(s):          1 Formulation(s)
             Drug Formulation 1 DFM Info click to show the detail info of this DFM
                   All DIGs    Click to Show/Hide the Full List of DIGs in This DFM
Propellant Hfa-134A; Ethanol
                   Dosage Form Aerosol
                   Company Mylan Specialty

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